| |  Online-Ressource |
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| Verfasst von: | Blume, Rachel [VerfasserIn]  |
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| | Rempel, Eugen [VerfasserIn] |
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| | Manta, Linda [VerfasserIn] |
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| | Saeed, Borhan R. [VerfasserIn] |
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| | Wang, Wenwen [VerfasserIn] |
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| | Raffel, Simon [VerfasserIn] |
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| | Ermakova, Olga [VerfasserIn] |
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| | Eckstein, Volker [VerfasserIn] |
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| | Trumpp, Andreas [VerfasserIn] |
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| | Ho, Anthony Dick [VerfasserIn] |
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| | Lutz, Christoph [VerfasserIn] |
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| Titel: | The molecular signature of AML with increased ALDH activity suggests a stem cell origin |
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| Verf.angabe: | Rachel Blume, Eugen Rempel, Linda Manta, Borhan R. Saeed, Wenwen Wang, Simon Raffel, Olga Ermakova, Volker Eckstein, Vladimir Benes, Andreas Trumpp, Anthony D. Ho & Christoph Lutz |
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| E-Jahr: | 2018 |
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| Jahr: | 16 Jan 2018 |
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| Umfang: | 10 S. |
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| Teil: | volume:59 |
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| | year:2018 |
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| | number:9 |
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| | pages:2201-2210 |
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| | extent:10 |
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| Fussnoten: | Gesehen am 22.10.2019 |
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| Titel Quelle: | Enthalten in: Leukemia and lymphoma |
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| Ort Quelle: | London [u.a.] : Taylor & Francis Group, 1989 |
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| Jahr Quelle: | 2018 |
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| Band/Heft Quelle: | 59(2018), 9, Seite 2201-2210 |
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| ISSN Quelle: | 1029-2403 |
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| Abstract: | Enrichment of leukemic blasts with a stem cell phenotype correlates with poor survival in acute myeloid leukemia (AML). In this context, measurement of the stem cell marker aldehyde-dehydrogenase (ALDH) activity can distinguish poor prognosis cases with increased fractions of ALDH-positive cells (ALDH-numerous AML) and favorable outcome cases with low percentages (ALDH-rare AML). It has been shown that ALDH-numerous AML favor leukemic engraftment in xenotransplantation assays which suggests increased leukemic stem cell (LSC) potential. To test if this reflects an immature cell of origin, comparative gene-expression studies of CD34+ leukemic blasts were performed. This analysis revealed increased expression of LSC and HSC signatures in ALDH-numerous AML, whereas ALDH-rare AML were enriched for a progenitor signature. The enrichment of stemness-associated transcriptional programs suggests that ALDH-numerous AML derive from immature hematopoietic progenitors and offers an explanation for the poor prognosis and therapy resistance of this subgroup which is likely caused by inherited stem cell properties. |
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| DOI: | doi:10.1080/10428194.2017.1422862 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1080/10428194.2017.1422862 |
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| | DOI: https://doi.org/10.1080/10428194.2017.1422862 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Acute myeloid leukemia |
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| | ALDH |
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| | gene-expression |
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| | leukemia stem cell |
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| K10plus-PPN: | 1679339702 |
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| Verknüpfungen: | → Zeitschrift |
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¬The¬ molecular signature of AML with increased ALDH activity suggests a stem cell origin / Blume, Rachel [VerfasserIn]; 16 Jan 2018 (Online-Ressource)
