| Online-Ressource |
Verfasst von: | Blume, Rachel [VerfasserIn]  |
| Rempel, Eugen [VerfasserIn]  |
| Manta, Linda [VerfasserIn]  |
| Saeed, Borhan R. [VerfasserIn]  |
| Wang, Wenwen [VerfasserIn]  |
| Raffel, Simon [VerfasserIn]  |
| Ermakova, Olga [VerfasserIn]  |
| Eckstein, Volker [VerfasserIn]  |
| Trumpp, Andreas [VerfasserIn]  |
| Ho, Anthony Dick [VerfasserIn]  |
| Lutz, Christoph [VerfasserIn]  |
Titel: | The molecular signature of AML with increased ALDH activity suggests a stem cell origin |
Verf.angabe: | Rachel Blume, Eugen Rempel, Linda Manta, Borhan R. Saeed, Wenwen Wang, Simon Raffel, Olga Ermakova, Volker Eckstein, Vladimir Benes, Andreas Trumpp, Anthony D. Ho & Christoph Lutz |
E-Jahr: | 2018 |
Jahr: | 16 Jan 2018 |
Umfang: | 10 S. |
Teil: | volume:59 |
| year:2018 |
| number:9 |
| pages:2201-2210 |
| extent:10 |
Fussnoten: | Gesehen am 22.10.2019 |
Titel Quelle: | Enthalten in: Leukemia and lymphoma |
Ort Quelle: | London [u.a.] : Taylor & Francis Group, 1989 |
Jahr Quelle: | 2018 |
Band/Heft Quelle: | 59(2018), 9, Seite 2201-2210 |
ISSN Quelle: | 1029-2403 |
Abstract: | Enrichment of leukemic blasts with a stem cell phenotype correlates with poor survival in acute myeloid leukemia (AML). In this context, measurement of the stem cell marker aldehyde-dehydrogenase (ALDH) activity can distinguish poor prognosis cases with increased fractions of ALDH-positive cells (ALDH-numerous AML) and favorable outcome cases with low percentages (ALDH-rare AML). It has been shown that ALDH-numerous AML favor leukemic engraftment in xenotransplantation assays which suggests increased leukemic stem cell (LSC) potential. To test if this reflects an immature cell of origin, comparative gene-expression studies of CD34+ leukemic blasts were performed. This analysis revealed increased expression of LSC and HSC signatures in ALDH-numerous AML, whereas ALDH-rare AML were enriched for a progenitor signature. The enrichment of stemness-associated transcriptional programs suggests that ALDH-numerous AML derive from immature hematopoietic progenitors and offers an explanation for the poor prognosis and therapy resistance of this subgroup which is likely caused by inherited stem cell properties. |
DOI: | doi:10.1080/10428194.2017.1422862 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1080/10428194.2017.1422862 |
| DOI: https://doi.org/10.1080/10428194.2017.1422862 |
Datenträger: | Online-Ressource |
Sprache: | eng |
Sach-SW: | Acute myeloid leukemia |
| ALDH |
| gene-expression |
| leukemia stem cell |
K10plus-PPN: | 1679339702 |
Verknüpfungen: | → Zeitschrift |
¬The¬ molecular signature of AML with increased ALDH activity suggests a stem cell origin / Blume, Rachel [VerfasserIn]; 16 Jan 2018 (Online-Ressource)