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| Verfasst von: | Hegazi, Nesrine M. [VerfasserIn]  |
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| | Sobeh, Mansour [VerfasserIn] |
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| | Rezq, Samar [VerfasserIn] |
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| | El-Raey, Mohamed A. [VerfasserIn] |
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| | Dmirieh, Malak [VerfasserIn] |
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| | El-Shazly, Assem M. [VerfasserIn] |
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| | Mahmoud, Mona F. [VerfasserIn] |
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| | Wink, Michael [VerfasserIn] |
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| Titel: | Characterization of phenolic compounds from Eugenia supra-axillaris leaf extract using HPLC-PDA-MS/MS and its antioxidant, anti-inflammatory, antipyretic and pain killing activities in vivo |
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| Verf.angabe: | Nesrine M. Hegazi, Mansour Sobeh, Samar Rezq, Mohamed A. El-Raey, Malak Dmirieh, Assem M. El-Shazly, Mona F. Mahmoud & Michael Wink |
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| E-Jahr: | 2019 |
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| Jahr: | 31 July 2019 |
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| Fussnoten: | Gesehen am 22.10.2019 |
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| Titel Quelle: | Enthalten in: Scientific reports |
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| Ort Quelle: | [London] : Macmillan Publishers Limited, part of Springer Nature, 2011 |
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| Jahr Quelle: | 2019 |
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| Band/Heft Quelle: | 9(2019) Artikel-Nummer 11122, 12 Seiten |
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| ISSN Quelle: | 2045-2322 |
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| Abstract: | Reactive oxygen species (ROS) are involved in the pathophysiology of several health disorders, among others inflammation. Polyphenols may modulate ROS related disorders. In this work, thirty-two phenolic compounds were tentatively identified in a leaf extract from Eugenia supra-axillaris Spring. ex Mart. using HPLC-MS/MS, five of which were also individually isolated and identified. The extract displayed a substantial in vitro antioxidant potential and was capable of decreasing ROS production and hsp-16.2 expression under oxidative stress conditions in vivo in the Caenorhabditis elegans model. Also, the extract showed higher inhibitory selectivity towards COX-2 than COX-1 in vitro with higher selectivity towards COX-2 than that of diclofenac. The extract also exhibited anti-inflammatory properties: It attenuated the edema thickness in a dose dependent fashion in carrageenan-induced hind-paw odema in rats. In addition, the extract reduced the carrageenan-induced leukocyte migration into the peritoneal cavity at the highest dose. Furthermore, the extract showed antipyretic and analgesic activities in a mouse model. Eugenia supra-axillaris appears to be a promising candidate in treating inflammation, pain and related oxidative stress diseases. |
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| DOI: | doi:10.1038/s41598-019-46946-7 |
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| URL: | Kostenfrei: Volltext ; Verlag: https://doi.org/10.1038/s41598-019-46946-7 |
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| | Kostenfrei: Volltext: https://www.nature.com/articles/s41598-019-46946-7 |
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| | DOI: https://doi.org/10.1038/s41598-019-46946-7 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1679351354 |
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| Verknüpfungen: | → Zeitschrift |
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| Lokale URL UB: |  Zum Volltext |
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Characterization of phenolic compounds from Eugenia supra-axillaris leaf extract using HPLC-PDA-MS/MS and its antioxidant, anti-inflammatory, antipyretic and pain killing activities in vivo / Hegazi, Nesrine M. [VerfasserIn]; 31 July 2019 (Online-Ressource)
