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Verfasst von:Hegazi, Nesrine M. [VerfasserIn]   i
 Sobeh, Mansour [VerfasserIn]   i
 Rezq, Samar [VerfasserIn]   i
 El-Raey, Mohamed A. [VerfasserIn]   i
 Dmirieh, Malak [VerfasserIn]   i
 El-Shazly, Assem M. [VerfasserIn]   i
 Mahmoud, Mona F. [VerfasserIn]   i
 Wink, Michael [VerfasserIn]   i
Titel:Characterization of phenolic compounds from Eugenia supra-axillaris leaf extract using HPLC-PDA-MS/MS and its antioxidant, anti-inflammatory, antipyretic and pain killing activities in vivo
Verf.angabe:Nesrine M. Hegazi, Mansour Sobeh, Samar Rezq, Mohamed A. El-Raey, Malak Dmirieh, Assem M. El-Shazly, Mona F. Mahmoud & Michael Wink
E-Jahr:2019
Jahr:31 July 2019
Fussnoten:Gesehen am 22.10.2019
Titel Quelle:Enthalten in: Scientific reports
Ort Quelle:[London] : Macmillan Publishers Limited, part of Springer Nature, 2011
Jahr Quelle:2019
Band/Heft Quelle:9(2019) Artikel-Nummer 11122, 12 Seiten
ISSN Quelle:2045-2322
Abstract:Reactive oxygen species (ROS) are involved in the pathophysiology of several health disorders, among others inflammation. Polyphenols may modulate ROS related disorders. In this work, thirty-two phenolic compounds were tentatively identified in a leaf extract from Eugenia supra-axillaris Spring. ex Mart. using HPLC-MS/MS, five of which were also individually isolated and identified. The extract displayed a substantial in vitro antioxidant potential and was capable of decreasing ROS production and hsp-16.2 expression under oxidative stress conditions in vivo in the Caenorhabditis elegans model. Also, the extract showed higher inhibitory selectivity towards COX-2 than COX-1 in vitro with higher selectivity towards COX-2 than that of diclofenac. The extract also exhibited anti-inflammatory properties: It attenuated the edema thickness in a dose dependent fashion in carrageenan-induced hind-paw odema in rats. In addition, the extract reduced the carrageenan-induced leukocyte migration into the peritoneal cavity at the highest dose. Furthermore, the extract showed antipyretic and analgesic activities in a mouse model. Eugenia supra-axillaris appears to be a promising candidate in treating inflammation, pain and related oxidative stress diseases.
DOI:doi:10.1038/s41598-019-46946-7
URL:Kostenfrei: Volltext ; Verlag: https://doi.org/10.1038/s41598-019-46946-7
 Kostenfrei: Volltext: https://www.nature.com/articles/s41598-019-46946-7
 DOI: https://doi.org/10.1038/s41598-019-46946-7
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1679351354
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