| |  Online-Ressource |
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| Verfasst von: | Schäfer, Michaela [VerfasserIn]  |
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| | Oeing, Christian [VerfasserIn] |
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| | Rohm, Maria [VerfasserIn] |
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| | Baysal-Temel, Ezgi [VerfasserIn] |
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| | Lehmann, Lorenz [VerfasserIn] |
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| | Bauer, Ralf [VerfasserIn] |
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| | Sticht, Carsten [VerfasserIn] |
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| | Gretz, Norbert [VerfasserIn] |
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| | Strobel, Oliver [VerfasserIn] |
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| | Hackert, Thilo [VerfasserIn] |
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| | Katus, Hugo [VerfasserIn] |
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| | Berriel Diaz, Mauricio [VerfasserIn] |
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| | Backs, Johannes [VerfasserIn] |
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| | Herzig, Stephan [VerfasserIn] |
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| Titel: | Ataxin-10 is part of a cachexokine cocktail triggering cardiac metabolic dysfunction in cancer cachexia |
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| Mitwirkende: | Boutros, Michael |
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| Verf.angabe: | Michaela Schäfer, Christian U. Oeing, Maria Rohm, Ezgi Baysal-Temel, Lorenz H. Lehmann, Ralf Bauer, H. Christian Volz, Michael Boutros, Daniela Sohn, Carsten Sticht, Norbert Gretz, Katrin Eichelbaum, Tessa Werner, Marc N. Hirt, Thomas Eschenhagen, Karin Müller-Decker, Oliver Strobel, Thilo Hackert, Jeroen Krijgsveld, Hugo A. Katus, Mauricio Berriel Diaz, Johannes Backs, Stephan Herzig |
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| E-Jahr: | 2016 |
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| Jahr: | February 2016 |
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| Umfang: | 12 S. |
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| Fussnoten: | Gesehen am 22.10.2019 |
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| Titel Quelle: | Enthalten in: Molecular metabolism |
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| Ort Quelle: | Oxford [u.a.] : Elsevier, 2012 |
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| Jahr Quelle: | 2016 |
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| Band/Heft Quelle: | 5(2016), 2, Seite 67-78 |
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| ISSN Quelle: | 2212-8778 |
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| Abstract: | Objectives - Cancer cachexia affects the majority of tumor patients and significantly contributes to high mortality rates in these subjects. Despite its clinical importance, the identity of tumor-borne signals and their impact on specific peripheral organ systems, particularly the heart, remain mostly unknown. - Methods and results - By combining differential colon cancer cell secretome profiling with large-scale cardiomyocyte phenotyping, we identified a signature panel of seven “cachexokines”, including Bridging integrator 1, Syntaxin 7, Multiple inositol-polyphosphate phosphatase 1, Glucosidase alpha acid, Chemokine ligand 2, Adamts like 4, and Ataxin-10, which were both sufficient and necessary to trigger cardiac atrophy and aberrant fatty acid metabolism in cardiomyocytes. As a prototypical example, engineered secretion of Ataxin-10 from non-cachexia-inducing cells was sufficient to induce cachexia phenotypes in cardiomyocytes, correlating with elevated Ataxin-10 serum levels in murine and human cancer cachexia models. - Conclusions - As Ataxin-10 serum levels were also found to be elevated in human cachectic cancer patients, the identification of Ataxin-10 as part of a cachexokine cocktail now provides a rational approach towards personalized predictive, diagnostic and therapeutic measures in cancer cachexia. |
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| DOI: | doi:10.1016/j.molmet.2015.11.004 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/j.molmet.2015.11.004 |
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| | Volltext: http://www.sciencedirect.com/science/article/pii/S2212877815002161 |
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| | DOI: https://doi.org/10.1016/j.molmet.2015.11.004 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Ataxin-10 |
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| | Cancer cachexia |
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| | Cardiac dysfunction |
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| | Fatty acid metabolism |
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| K10plus-PPN: | 1679363212 |
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| Verknüpfungen: | → Zeitschrift |
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Ataxin-10 is part of a cachexokine cocktail triggering cardiac metabolic dysfunction in cancer cachexia / Schäfer, Michaela [VerfasserIn]; February 2016 (Online-Ressource)
