Biosimilars of low-molecular-weight heparin products

• Verfasst von: Harenberg, Job [VerfasserIn]
• Titel: Biosimilars of low-molecular-weight heparin products
• Titelzusatz: fostering competition or reducing ‘biodiversity’?
• Verf.angabe: J. Harenberg, C. Cimminiello, G. Agnelli, G. Di Minno, H. Polo Friz, P. Prandoni and F. Scaglione
• Jahr: 2016
• Umfang: 6 S.
• Fussnoten: Gesehen am 24.10.2019 ; First published: 29 December 2015
• Titel Quelle: Enthalten in: Journal of thrombosis and haemostasis
• Ort Quelle: [Amsterdam] : Elsevier, 2003
• Jahr Quelle: 2016
• Band/Heft Quelle: 14(2016), 3, Seite 421-426
• ISSN Quelle: 1538-7836
• DOI: doi:10.1111/jth.13237
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: biosimilar pharmaceuticals
• Sach-SW: evidence-based practise
• Sach-SW: low-molecular-weight heparin
• Sach-SW: therapeutic equivalency
• Sach-SW: venous thromboembolism
• K10plus-PPN: 1679771086

Abstract

The term ‘biosimilars’ is used to qualify products developed to be similar to an original biological drug. Biosimilars are much more complicated to develop than a generic version of small-molecule drugs and this is especially true for low-molecular-weight heparins (LMWHs). Evidence on the antithrombotic management of acute coronary syndromes (ACS) showed that the introduction into the market of biosimilars approved on the basis of simple biological criteria, without robust data from comparative clinical trials, may be hazardous. Moreover, the mixtures of LMWH polysaccharide chains, some immunoallergic properties and potential contamination during the extraction process raise safety concerns. As was the case for the biosimilar erythropoietin, there is the risk that only copies of the most commercially successful LMWHs will be marketed, thus jeopardizing the ‘biodiversity’ now ensured by the presence of several LMWHs, each with unique features that support the use of an individual LMWH as first-choice therapy in certain categories of patients.