Status: Bibliographieeintrag
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| |  Online-Ressource |
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| Verfasst von: | Patzke, Christopher [VerfasserIn]  |
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| | Acuna Goycolea, Claudio [VerfasserIn] |
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| Titel: | Neuromodulator signaling bidirectionally controls vesicle numbers in human synapses |
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| Verf.angabe: | Christopher Patzke, Marisa M. Brockmann, Jinye Dai, Kathlyn J. Gan, M. Katharina Grauel, Pascal Fenske, Yu Liu, Claudio Acuna, Christian Rosenmund, and Thomas C. Südhof |
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| E-Jahr: | 2019 |
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| Jahr: | 3 October 2019 |
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| Umfang: | 39 S. |
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| Fussnoten: | Gesehen am 25.10.2019 |
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| Titel Quelle: | Enthalten in: Cell |
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| Ort Quelle: | [Cambridge, Mass.] : Cell Press, 1974 |
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| Jahr Quelle: | 2019 |
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| Band/Heft Quelle: | 179(2019), 2, Seite 498-513.e22 |
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| ISSN Quelle: | 1097-4172 |
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| Abstract: | Neuromodulators bind to pre- and postsynaptic G protein-coupled receptors (GPCRs), are able to quickly change intracellular cyclic AMP (cAMP) and Ca2+ levels, and are thought to play important roles in neuropsychiatric and neurodegenerative diseases. Here, we discovered in human neurons an unanticipated presynaptic mechanism that acutely changes synaptic ultrastructure and regulates synaptic communication. Activation of neuromodulator receptors bidirectionally controlled synaptic vesicle numbers within nerve terminals. This control correlated with changes in the levels of cAMP-dependent protein kinase A-mediated phosphorylation of synapsin-1. Using a conditional deletion approach, we reveal that the neuromodulator-induced control of synaptic vesicle numbers was largely dependent on synapsin-1. We propose a mechanism whereby non-phosphorylated synapsin-1 “latches” synaptic vesicles to presynaptic clusters at the active zone. cAMP-dependent phosphorylation of synapsin-1 then removes the vesicles. cAMP-independent dephosphorylation of synapsin-1 in turn recruits vesicles. Synapsin-1 thereby bidirectionally regulates synaptic vesicle numbers and modifies presynaptic neurotransmitter release as an effector of neuromodulator signaling in human neurons. |
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| DOI: | doi:10.1016/j.cell.2019.09.011 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/j.cell.2019.09.011 |
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| | Verlag: http://www.sciencedirect.com/science/article/pii/S0092867419310177 |
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| | DOI: https://doi.org/10.1016/j.cell.2019.09.011 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | cAMP |
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| | guanfacine |
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| | high-pressure freeze EM |
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| | human synapse |
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| | neuromodulator |
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| | norepinephrine |
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| | old human neurons |
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| | serotonin |
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| | synapsin-1 |
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| | synaptic vesicles |
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| K10plus-PPN: | 1680004409 |
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| Verknüpfungen: | → Zeitschrift |
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Neuromodulator signaling bidirectionally controls vesicle numbers in human synapses / Patzke, Christopher [VerfasserIn]; 3 October 2019 (Online-Ressource)
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