Systematic review of the pharmacological agents that have been tested against spreading depolarizations

• Verfasst von: Klass, Anna [VerfasserIn]
• Verfasst von: Sánchez-Porras, Renán [VerfasserIn]
• Verfasst von: Santos, Edgar [VerfasserIn]
• Titel: Systematic review of the pharmacological agents that have been tested against spreading depolarizations
• Verf.angabe: Anna Klass, Renan Sánchez-Porras and Edgar Santos
• E-Jahr: 2018
• Jahr: April 20, 2018
• Umfang: 31 S.
• Fussnoten: Gesehen am 28.10.2019
• Titel Quelle: Enthalten in: Journal of cerebral blood flow & metabolism
• Ort Quelle: Thousands Oaks, Calif. : Sage, 1981
• Jahr Quelle: 2018
• Band/Heft Quelle: 38(2018), 7, Seite 1149-1179
• ISSN Quelle: 1559-7016
• DOI: doi:10.1177/0271678X18771440
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1680045296

Abstract

Spreading depolarization (SD) occurs alongside brain injuries and it can lead to neuronal damage. Therefore, pharmacological modulation of SD can constitute a therapeutic approach to reduce its detrimental effects and to improve the clinical outcome of patients. The major objective of this article was to produce a systematic review of all the drugs that have been tested against SD. Of the substances that have been examined, most have been shown to modulate certain SD characteristics. Only a few have succeeded in significantly inhibiting SD. We present a variety of strategies that have been proposed to overcome the notorious harmfulness and pharmacoresistance of SD. Information on clinically used anesthetic, sedative, hypnotic agents, anti-migraine drugs, anticonvulsants and various other substances have been compiled and reviewed with respect to the efficacy against SD, in order to answer the question of whether a drug at safe doses could be of therapeutic use against SD in humans.