Lung cancer

• Verfasst von: Petersen, Iver [VerfasserIn]
• Verfasst von: Warth, Arne [VerfasserIn]
• Titel: Lung cancer
• Titelzusatz: developments, concepts, and specific aspects of the new WHO classification
• Verf.angabe: Iver Petersen, Arne Warth
• Jahr: 2016
• Jahr des Originals: 2016
• Umfang: 10 S.
• Fussnoten: Published online: 22 July 2015 ; Gesehen am 29.10.2019
• Titel Quelle: Enthalten in: Journal of cancer research and clinical oncology
• Ort Quelle: Berlin : Springer, 1904
• Jahr Quelle: 2016
• Band/Heft Quelle: 142(2016), 5, Seite 895-904
• ISSN Quelle: 1432-1335
• DOI: doi:10.1007/s00432-015-2004-4
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Classification
• Sach-SW: Diagnosis
• Sach-SW: Immunohistochemistry
• Sach-SW: Lung cancer
• Sach-SW: Molecular pathology
• K10plus-PPN: 1680633090

Abstract

Introduction Diagnostic methods and algorithms for the diagnosis of pulmonary neoplasms have considerably changed over the recent years. Based on large-scale molecular characterization studies and the development of targeted therapies, precise morphological, immunohistochemical, and molecular pathological tumor subtyping is now of utmost importance for evidence-based treatment decisions. Changes of diagnostic concepts initially referred to biopsies and cytology specimens but are now also transferred to resection specimens.Methods This review is focused on recent developments in morphological and immunohistochemical subtyping of pulmonary neoplasms and concepts of tumor progression. It also provides perspectives on relevant changes of diagnostic concepts within the context of the new WHO classification.ConclusionIt becomes apparent that a three-step diagnostic concept based on morphology, immunohistochemistry, and molecular pathology is important to meet the requirements of an increasingly more complex, interdisciplinary care of lung cancer patients and to allow for reliable, clinically meaningful tumor diagnoses.