| |  Online-Ressource |
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| Verfasst von: | Schölch, Sebastian [VerfasserIn]  |
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| | Rahbari, Mohammad [VerfasserIn] |
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| | Schneider, Martin [VerfasserIn] |
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| | Reißfelder, Christoph [VerfasserIn] |
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| | Rahbari, Nuh Nabi [VerfasserIn] |
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| Titel: | Serum PlGF and EGF are independent prognostic markers in non-metastatic colorectal cancer |
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| Verf.angabe: | Sebastian Schölch, Andreas Bogner, Ulrich Bork, Mohammad Rahbari, Balázs Győrffy, Martin Schneider, Christoph Reissfelder, Jürgen Weitz & Nuh N. Rahbari |
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| E-Jahr: | 2019 |
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| Jahr: | 29 July 2019 |
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| Umfang: | 12 S. |
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| Fussnoten: | Gesehen am 29.10.2019 |
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| Titel Quelle: | Enthalten in: Scientific reports |
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| Ort Quelle: | [London] : Springer Nature, 2011 |
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| Jahr Quelle: | 2019 |
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| Band/Heft Quelle: | 9(2019) Artikel-Nummer 10921, 12 Seiten |
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| ISSN Quelle: | 2045-2322 |
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| Abstract: | The aim of this study was to determine the prognostic value of circulating angiogenic cytokines in non-metastatic colorectal cancer (CRC) patients. Preoperative serum samples of a training (TC) (n = 219) and a validation cohort (VC) (n = 168) were analyzed via ELISA to determine PlGF, EGF, VEGF, Ang1, PDGF-A, PDGF-B, IL-8 and bFGF levels. In addition, survival was correlated with PlGF and EGF expression measured by microarray and RNAseq in two publicly available, independent cohorts (n = 550 and n = 463, respectively). Prognostic values for overall (OS) and disease-free survival (DFS) were determined using uni- and multivariate Cox proportional hazard analyses. Elevated PlGF is predictive for impaired OS (TC: HR 1.056; p = 0.046; VC: HR 1.093; p = 0.001) and DFS (TC: HR 1.052; p = 0.029; VC: HR 1.091; p = 0.009). Conversely, elevated EGF is associated with favorable DFS (TC: HR 0.998; p = 0.045; VC: HR 0.998; p = 0.018) but not OS (TC: p = 0.201; VC: p = 0.453). None of the other angiogenic cytokines correlated with prognosis. The prognostic value of PlGF (OS + DFS) and EGF (DFS) was confirmed in both independent retrospective cohorts. Serum PlGF and EGF may serve as prognostic markers in non-metastatic CRC. |
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| DOI: | doi:10.1038/s41598-019-47429-5 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1038/s41598-019-47429-5 |
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| | Verlag: https://www.nature.com/articles/s41598-019-47429-5 |
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| | DOI: https://doi.org/10.1038/s41598-019-47429-5 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1680635344 |
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| Verknüpfungen: | → Zeitschrift |
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Serum PlGF and EGF are independent prognostic markers in non-metastatic colorectal cancer / Schölch, Sebastian [VerfasserIn]; 29 July 2019 (Online-Ressource)
