Individualization of post-mastectomy radiotherapy and regional nodal irradiation based on treatment response after neoadjuvant chemotherapy for breast cancer

• Verfasst von: Krug, David [VerfasserIn]
• Verfasst von: Wenz, Frederik [VerfasserIn]
• Titel: Individualization of post-mastectomy radiotherapy and regional nodal irradiation based on treatment response after neoadjuvant chemotherapy for breast cancer
• Verf.angabe: David Krug, René Baumann, Wilfried Budach, Jürgen Dunst, Petra Feyer, Rainer Fietkau, Wulf Haase, Wolfgang Harms, Thomas Hehr, Marc D. Piroth, Felix Sedlmayer, Rainer Souchon, Frederik Wenz, Rolf Sauer
• E-Jahr: 2018
• Jahr: 30 January 2018
• Umfang: 12 S.
• Fussnoten: Gesehen am 30.10.2019
• Titel Quelle: Enthalten in: Strahlentherapie und Onkologie
• Ort Quelle: Berlin : Springer Medizin, 1997
• Jahr Quelle: 2018
• Band/Heft Quelle: 194(2018), 7, Seite 607-618
• ISSN Quelle: 1439-099X
• DOI: doi:10.1007/s00066-018-1270-x
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Breast neoplasms
• Sach-SW: Brustkrebs
• Sach-SW: Local recurrence
• Sach-SW: Lokalrezidiv
• Sach-SW: Neoadjuvant therapy
• Sach-SW: Neoadjuvante Therapie
• Sach-SW: Radiotherapy
• Sach-SW: Strahlentherapie
• K10plus-PPN: 1680701185

Abstract

PurposeTo review the evidence regarding post-mastectomy radiotherapy (PMRT) and regional nodal irradiation (RNI) after neoadjuvant chemotherapy (NACT) for breast cancer, with a special focus on individualization of adjuvant radiotherapy based on treatment response.MethodsA systematic literature search using the PubMed/Medline database was performed. We included prospective and retrospective reports with a minimum of 10 patients that had been published since 1st January 2000, and provided clinical outcome data analyzed by treatment response and radiotherapy.ResultsOut of 763 articles identified via PubMed/Medline and hand search, 68 full text-articles were assessed for eligibility after screening of title and abstract. 13 studies were included in the systematic review, 9 for PMRT and 5 for RNI. All included studies were retrospective reports.ConclusionsThere is a considerable lack of evidence regarding the role of adjuvant radiotherapy and its individualization based on treatment response after NACT. Results of prospective randomized trials such as NSABP B‑51/RTOG 1304 and Alliance A11202 are eagerly awaited.