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Verfasst von:Frank, Sabine [VerfasserIn]   i
 Friederich, Hans-Christoph [VerfasserIn]   i
Titel:Dopamine depletion reduces food-related reward activity independent of BMI
Verf.angabe:Sabine Frank, Ralf Veit, Helene Sauer, Paul Enck, Hans-Christoph Friederich, Theresa Unholzer, Ute-Maria Bauer, Katarzyna Linder, Martin Heni, Andreas Fritsche, and Hubert Preissl
Jahr:2016
Jahr des Originals:2015
Umfang:9 S.
Fussnoten:published online 4 November 2015 ; Gesehen am 30.10.2019
Titel Quelle:Enthalten in: Neuropsychopharmacology
Ort Quelle:London : Springer Nature, 1993
Jahr Quelle:2016
Band/Heft Quelle:41(2016), 6, Seite 1551-1559
ISSN Quelle:1740-634X
Abstract:Reward sensitivity and possible alterations in the dopaminergic-reward system are associated with obesity. We therefore aimed to investigate the influence of dopamine depletion on food-reward processing. We investigated 34 female subjects in a randomized placebo-controlled, within-subject design (body mass index (BMI)=27.0 kg/m2 ±4.79 SD; age=28 years ±4.97 SD) using an acute phenylalanine/tyrosine depletion drink representing dopamine depletion and a balanced amino acid drink as the control condition. Brain activity was measured with functional magnetic resonance imaging during a ‘wanting’ and ‘liking’ rating of food items. Eating behavior-related traits and states were assessed on the basis of questionnaires. Dopamine depletion resulted in reduced activation in the striatum and higher activation in the superior frontal gyrus independent of BMI. Brain activity during the wanting task activated a more distributed network than during the liking task. This network included gustatory, memory, visual, reward, and frontal regions. An interaction effect of dopamine depletion and the wanting/liking task was observed in the hippocampus. The interaction with the covariate BMI was significant in motor and control regions but not in the striatum. Our results support the notion of altered brain activity in the reward and prefrontal network with blunted dopaminergic action during food-reward processing. This effect is, however, independent of BMI, which contradicts the reward-deficiency hypothesis. This hints to the hypothesis suggesting a different or more complex mechanism underlying the dopaminergic reward function in obesity.
DOI:doi:10.1038/npp.2015.313
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: https://doi.org/10.1038/npp.2015.313
 Volltext: https://www.nature.com/articles/npp2015313
 DOI: https://doi.org/10.1038/npp.2015.313
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1680735454
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