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Status: Bibliographieeintrag

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Verfasst von:Selim, Nabil [VerfasserIn]   i
 Sobeh, Mansour [VerfasserIn]   i
Titel:Chrysophanol, physcion, hesperidin and curcumin modulate the gene expression of pro-inflammatory mediators induced by LPS in HepG2
Titelzusatz:in silico and molecular studies
Verf.angabe:Nabil Mohamed Selim, Abdullah Abdurrahman Elgazar, Nabil Mohie Abdel-Hamid, Mohammed Rizk Abu El-Magd, Aziz Yasri, Hala Mohamed El Hefnawy and Mansour Sobeh
E-Jahr:2019
Jahr:3 September 2019
Umfang:23 S.
Fussnoten:Gesehen am 31.10.2019
Titel Quelle:Enthalten in: Antioxidants
Ort Quelle:Basel : MDPI, 2013
Jahr Quelle:2019
Band/Heft Quelle:8(2019,9) Artikel-Nummer 371, 23 Seiten
ISSN Quelle:2076-3921
Abstract:Hepatitis is an inflammatory condition that can develop hepatocellular carcinoma. Traditional medicine has always been the pillar of medical practice. However, it became less compatible with the current understanding of the diseases and the possible treatment. Therefore, in silico tools could be utilized for building the bridge between the legacy of the past and the current medical approaches allowing access to new therapeutic discoveries. In this work, a Chinese traditional medicine database was screened using structure-based virtual screening to identify molecules that could inhibit p38 alpha mitogen-activated protein kinase (MAPK). Out of the identified compounds, four selected compounds: chrysophanol, physcion, curcumin and hesperidin were isolated from their respective sources and their structures were confirmed by spectroscopic methods. These compounds decreased the gene expression of tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6) and interleukin-1beta (IL-1β) in lipopolysaccharide (LPS) induced inflammation in a hepatocellular carcinoma cell line (HepG2) in a dose-dependent manner. The molecular docking study revealed the specificity of these compounds towards p38 MAPK rather than other MAPKs. In conclusion, the molecular and in silico studies suggest that the isolated compounds could be a potential treatment for hepatitis by resolving inflammation controlled by MAPKs, thus limiting the development of further complications and lower side effects.
DOI:doi:10.3390/antiox8090371
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.3390/antiox8090371
 Verlag: https://www.mdpi.com/2076-3921/8/9/371
 DOI: https://doi.org/10.3390/antiox8090371
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:hepatoprotective
 in silico screening
 molecular docking
 p38 MAPK
 phenolics
K10plus-PPN:1680803395
Verknüpfungen:→ Zeitschrift

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