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Verfasst von:Ghareeb, Mosad Ahmed [VerfasserIn]   i
 Sobeh, Mansour [VerfasserIn]   i
 Wink, Michael [VerfasserIn]   i
Titel:Chemical profiling of polyphenolics in Eucalyptus globulus and evaluation of its hepato-renal protective potential against cyclophosphamide induced toxicity in mice
Verf.angabe:Mosad A. Ghareeb, Mansour Sobeh, Walaa H. El-Maadawy, Hala Sh Mohammed, Heba Khalil, Sanaa Botros and Michael Wink
E-Jahr:2019
Jahr:19 September 2019
Umfang:19 S.
Fussnoten:Gesehen am 31.10.2019
Titel Quelle:Enthalten in: Antioxidants
Ort Quelle:Basel : MDPI, 2013
Jahr Quelle:2019
Band/Heft Quelle:8(2019,9) Artikel-Nummer 415, 19 Seiten
ISSN Quelle:2076-3921
Abstract:Cyclophosphamide (CP) is a potent anti-neoplastic and immunosuppressive agent; however, it causes multi-organ toxicity. We elucidated the protective activities of Eucalyptus globulus (EG) leaf extract against CP-induced hepato–renal toxicity. Mice were treated with EG for 15 days plus CP on day 12 and 13 of the experiment. Using HPLC-DAD-ESI-MS/MS, 26 secondary metabolites were identified in EG leaf extract. Out of them, 4 polyphenolic compounds were isolated: (1) 4-(O-β-d-xylopyranosyloxy)-3,5-di-hydroxy-benzoic acid, (2) 4-(O-α-l-rhamnopyranosyloxy)-3,5-di-hydroxy-benzoic acid, (3) gallic acid, and (4) methyl gallate. Effects of EG extract on biochemical parameters, gene expression, and immune-histopathological changes were assessed in comparison to mesna positive control. Results showed that EG improved CP-increased serum ALT, AST, creatinine, and blood urea nitrogen levels. The hepatic and renal tissue levels of MDA, nitric oxide, protein carbonyl, TNF-α, IL-6, and immunohistochemical expression of nuclear factor kappa-B (NF-kB) and caspase-3 were reduced. Also, hepatic and renal GSH contents, and nuclear factor E2-related factor 2 (NRf2)/ hemoxygenase-1 (HO-1) signaling levels were increased. Histopathological findings supported our findings where hepatic and renal architecture were almost restored. Results revealed the protective effects of EG against CP-induced hepato–renal toxicity. These effects may be related to EG antioxidant, anti-inflammatory, and anti-apoptotic properties coupled with activation of Nrf2/HO-1 signaling.
DOI:doi:10.3390/antiox8090415
URL:Volltext: https://doi.org/10.3390/antiox8090415
 Verlag: https://www.mdpi.com/2076-3921/8/9/415
 DOI: https://doi.org/10.3390/antiox8090415
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:<i>Eucalyptus globulus</i>
 anti-inflammatory
 antioxidant
 cyclophosphamide
 hepatotoxicity
 nephrotoxicity
 Nrf2/HO-1 signaling
 polyphenolics
K10plus-PPN:1680805053
Verknüpfungen:→ Zeitschrift
 
 
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