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Status: Bibliographieeintrag

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Verfasst von:Grafetstätter, Mirja [VerfasserIn]   i
 Pletsch-Borba, Laura [VerfasserIn]   i
 Johnson, Theron S. [VerfasserIn]   i
 Katzke, Verena [VerfasserIn]   i
 Hoffmeister, Michael [VerfasserIn]   i
 Bugert, Peter [VerfasserIn]   i
 Kaaks, Rudolf [VerfasserIn]   i
 Kühn, Tilman [VerfasserIn]   i
Titel:Thrombomodulin and thrombopoietin, two biomarkers of hemostasis, are positively associated with adherence to the World Cancer Research Fund/American Institute for Cancer Research Recommendations for Cancer Prevention in a population-based cross-sectional study
Verf.angabe:Mirja Grafetstätter, Laura Pletsch-Borba, Disorn Sookthai, Nena Karavasiloglou, Theron Johnson, Verena A. Katzke, Michael Hoffmeister, Peter Bugert, Rudolf Kaaks and Tilman Kühn
E-Jahr:2019
Jahr:3 September 2019
Umfang:15 S.
Fussnoten:Gesehen am 31.10.2019
Titel Quelle:Enthalten in: Nutrients
Ort Quelle:Basel : MDPI, 2009
Jahr Quelle:2019
Band/Heft Quelle:11(2019,9) Artikel-Nummer 2067, 15 Seiten
ISSN Quelle:2072-6643
Abstract:A pro-coagulative state is related to increased risk of cardiovascular diseases but also certain cancers. Since experimental and smaller human studies suggest that diet, physical activity, and body weight may all affect coagulation, we evaluated associations between these lifestyle factors and hemostatic biomarkers in a population-based study. Cross-sectional baseline data from 2267 randomly selected participants of EPIC-Heidelberg (age range 35–65 years) was used. Fibrinogen, glycoprotein IIb/IIIa, P-selectin, thrombomodulin (TM), and thrombopoietin (TPO) were measured in baseline plasma samples. A score reflecting adherence to the World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) recommendations for cancer prevention was created. Associations between the WCRF/AICR score as well as its individual components and hemostatic biomarkers were analyzed by linear regression models. Multivariable-adjusted geometric means (95% confidence intervals) of TM and TPO were higher with greater adherence to the WCRF/AICR recommendations (TM, lowest vs. highest score category: 2.90 (2.7,3.1) vs. 3.10 (2.9,3.3) ng/mL, plinear trend = 0.0001; TPO: 328 (302,356) vs. 348 (321,378) pg/mL, plinear trend = 0.0007). These associations were driven by lower alcohol and meat consumption among persons with higher WCRF/AICR scores. Our results indicate that lifestyle factors favorably affect TM and TPO, two hemostatic factors implicated in chronic disease development.
DOI:doi:10.3390/nu11092067
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.3390/nu11092067
 Verlag: https://www.mdpi.com/2072-6643/11/9/2067
 DOI: https://doi.org/10.3390/nu11092067
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:cancer prevention
 coagulation
 fibrinogen
 lifestyle
 thrombomodulin
 thrombopoietin
 WCRF/AICR recommendations
K10plus-PPN:1680805754
Verknüpfungen:→ Zeitschrift

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