Status: Bibliographieeintrag
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| Verfasst von: | Kennel, Kilian [VerfasserIn]  |
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| | Burmeister, Julius [VerfasserIn] |
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| | Schneider, Martin [VerfasserIn] |
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| | Taylor, Cormac T. [VerfasserIn] |
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| Titel: | The PHD1 oxygen sensor in health and disease |
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| Verf.angabe: | Kilian B. Kennel, Julius Burmeister, Martin Schneider and Cormac T. Taylor |
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| E-Jahr: | 2018 |
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| Jahr: | 13 February 2018 |
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| Umfang: | 15 S. |
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| Fussnoten: | Gesehen am 31.10.2019 |
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| Titel Quelle: | Enthalten in: The journal of physiology |
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| Ort Quelle: | Hoboken, NJ : Wiley-Blackwell, 1878 |
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| Jahr Quelle: | 2018 |
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| Band/Heft Quelle: | 596(2018), 17, Seite 3899-3913 |
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| ISSN Quelle: | 1469-7793 |
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| Abstract: | The hypoxia-inducible factor (HIF) co-ordinates the adaptive transcriptional response to hypoxia in metazoan cells. The hypoxic sensitivity of HIF is conferred by a family of oxygen-sensing enzymes termed HIF hydroxylases. This family consists of three prolyl hydroxylases (PHD1-3) and a single asparagine hydroxylase termed factor inhibiting HIF (FIH). It has recently become clear that HIF hydroxylases are functionally non-redundant and have discrete but overlapping physiological roles. Furthermore, altered abundance or activity of these enzymes is associated with a number of pathologies. Pharmacological HIF-hydroxylase inhibitors have recently proven to be both tolerated and therapeutically effective in patients. In this review, we focus on the physiology, pathophysiology and therapeutic potential of the PHD1 isoform, which has recently been implicated in diseases including inflammatory bowel disease, ischaemia and cancer. |
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| DOI: | doi:10.1113/JP275327 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1113/JP275327 |
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| | Volltext: https://physoc.onlinelibrary.wiley.com/doi/abs/10.1113/JP275327 |
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| | DOI: https://doi.org/10.1113/JP275327 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | apoptosis |
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| | cancer |
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| | colitis |
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| | HIF |
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| | hypoxia-inducible factor |
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| | inflammatory bowel disease |
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| | ischemia |
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| | NF-κB |
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| | PHD inhibitor |
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| | PHD1 |
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| | Prolyl-hydroxylase 1 |
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| K10plus-PPN: | 1680818392 |
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| Verknüpfungen: | → Zeitschrift |
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¬The¬ PHD1 oxygen sensor in health and disease / Kennel, Kilian [VerfasserIn]; 13 February 2018 (Online-Ressource)
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