| |  Online-Ressource |
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| Verfasst von: | Linnebacher, Alica [VerfasserIn]  |
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| | Mayer, Philipp [VerfasserIn] |
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| | Marnet, Nicole [VerfasserIn] |
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| | Bergmann, Frank [VerfasserIn] |
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| | Herpel, Esther [VerfasserIn] |
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| | Revia, Steffie [VerfasserIn] |
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| | Yin, Libo [VerfasserIn] |
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| | Liu, Li [VerfasserIn] |
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| | Hackert, Thilo [VerfasserIn] |
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| | Giese, Thomas [VerfasserIn] |
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| | Herr, Ingrid [VerfasserIn] |
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| | Gaida, Matthias [VerfasserIn] |
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| Titel: | Interleukin 21 receptor/ligand interaction is linked to disease progression in pancreatic cancer |
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| Verf.angabe: | Alica Linnebacher, Philipp Mayer, Nicole Marnet, Frank Bergmann, Esther Herpel, Steffie Revia, Libo Yin, Li Liu, Thilo Hackert, Thomas Giese, Ingrid Herr and Matthias M. Gaida |
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| E-Jahr: | 2019 |
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| Jahr: | 18 September 2019 |
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| Umfang: | 18 S. |
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| Fussnoten: | Gesehen am 31.10.2019 |
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| Titel Quelle: | Enthalten in: Cells |
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| Ort Quelle: | Basel : MDPI, 2012 |
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| Jahr Quelle: | 2019 |
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| Band/Heft Quelle: | 8(2019), 9, Artikel-ID 1104, Seite 1-18 |
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| ISSN Quelle: | 2073-4409 |
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| Abstract: | Pancreatic ductal adenocarcinoma (PDAC) displays a marked fibro-inflammatory microenvironment in which infiltrated immune cells fail to eliminate the tumor cells and often—rather paradoxically—promote tumor progression. Of special interest are tumor-promoting T cells that assume a Th17-like phenotype because their presence in PDAC tissue is associated with a poor prognosis. In that context, the role of IL-21, a major cytokine released by Th17-like cells, was assessed. In all tissue samples (n = 264) IL-21+ immune cells were detected by immunohistochemistry and high density of those cells was associated with poor prognosis. In the majority of patients (221/264), tumor cells expressed the receptor for IL-21 (IL-21R) and also a downstream target of IL-21, Blimp-1 (199/264). Blimp-1 expression closely correlated with IL-21R expression and multivariate analysis revealed that expression of both IL-21R and Blimp-1 was associated with shorter survival time of the patients. In vitro data using pancreatic tumor cells lines provided a possible explanation: IL-21 activated ERK and STAT3 pathways and upregulated Blimp-1. Moreover, IL-21 increased invasion of tumor cell lines in a Blimp-1-dependent manner. As an in vivo correlate, an avian xenograft model was used. Here again Blimp-1 expression was significantly upregulated in IL-21 stimulated tumor cells. In summary, our data showed an association of IL-21+ immune cell infiltration and IL-21 receptor expression in PDAC with poor survival, most likely due to an IL-21-mediated promotion of tumor cell invasion and enhanced colony formation, supporting the notion of the tumor-promoting abilities of the tumor microenvironment. |
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| DOI: | doi:10.3390/cells8091104 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.3390/cells8091104 |
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| | Verlag: https://www.mdpi.com/2073-4409/8/9/1104 |
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| | DOI: https://doi.org/10.3390/cells8091104 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Blimp-1 |
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| | IL-21 |
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| | invasion |
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| | pancreatic cancer |
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| | Th17 |
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| | tumor microenvironment |
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| K10plus-PPN: | 1680821555 |
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| Verknüpfungen: | → Zeitschrift |
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Interleukin 21 receptor/ligand interaction is linked to disease progression in pancreatic cancer / Linnebacher, Alica [VerfasserIn]; 18 September 2019 (Online-Ressource)
