| Online-Ressource |
Verfasst von: | Friedrich, Kilian [VerfasserIn]  |
| Schamoni, Shigehiko [VerfasserIn]  |
| Wenz, Theresa [VerfasserIn]  |
| Pfeiffenberger, Jan [VerfasserIn]  |
| Rupp, Christian [VerfasserIn]  |
| Gotthardt, Daniel [VerfasserIn]  |
| Houben, Philipp [VerfasserIn]  |
| Haken, Rebecca von [VerfasserIn]  |
| Heininger, Alexandra [VerfasserIn]  |
| Brenner, Thorsten [VerfasserIn]  |
| Mehrabi, Arianeb [VerfasserIn]  |
| Weiss, Karl Heinz [VerfasserIn]  |
| Mieth, Markus [VerfasserIn]  |
Titel: | Multidrug-resistant bacteria and disease progression in patients with end-stage liver disease and after liver transplantation |
Verf.angabe: | Kilian Friedrich, Jessica Krempl, Shigehiko Schamoni, Theresa Hippchen, Jan Pfeiffenberger, Christian Rupp, Daniel Nils Gotthardt, Philip Houben, Rebecca von Haken, Alexandra Heininger, Thorsten Brenner, Arianeb Mehrabi, Karl-Heinz Weiss, Markus Mieth |
E-Jahr: | 2019 |
Jahr: | 13 July 2019 |
Umfang: | 9 S. |
Fussnoten: | Gesehen am 04.11.2019 |
Titel Quelle: | Enthalten in: Journal of gastrointestinal and liver diseases |
Ort Quelle: | Cluj-Napoca : Soc., 2006 |
Jahr Quelle: | 2019 |
Band/Heft Quelle: | 28(2019), 3, Seite 303-310 |
ISSN Quelle: | 1842-1121 |
Abstract: | Background: Multidrug-resistant (MDR) pathogens represent an emerging challenge in end-stage liver disease and in liver transplant recipients. - Methods: We evaluated the impact of MDR bacteria upon clinical outcomes in patients with end-stage liver disease (n = 777) at the time of enrollment on the liver transplant (LTx) waiting list, after first LTx (n = 645), and after second LTx (n = 128). - Results: Colonization/infection with MDR bacteria was present in 72/777 patients on the waiting list, in 98/645 patients at first LTx, and in 46/128 patients at second LTx. While on the LTx waiting list, the time until first hydropic decompensation (p = 0.021), hepatic encephalopathy (p < 0.001) and hepatorenal syndrome (p < 0.001) was reduced in the presence of MDR bacteria, which remained an independent risk factor of poor survival in multivariate analysis (p < 0.001). Following first and second liver transplant, MDR bacteria were associated with an increased risk of infection-related deaths (first LTx: p < 0.001; second LTx: p = 0.037) and reduced actuarial survival (first LTx: p < 0.001; second LTx: p = 0.046). - Conclusions: We showed that MDR pathogens are associated with poor outcomes before, after first and after recurrent LTx. |
DOI: | doi:10.15403/jgld-212 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.15403/jgld-212 |
| Verlag: https://www.jgld.ro/jgld/index.php/jgld/article/view/212 |
| DOI: https://doi.org/10.15403/jgld-212 |
Datenträger: | Online-Ressource |
Sprache: | eng |
K10plus-PPN: | 168088736X |
Verknüpfungen: | → Zeitschrift |
Multidrug-resistant bacteria and disease progression in patients with end-stage liver disease and after liver transplantation / Friedrich, Kilian [VerfasserIn]; 13 July 2019 (Online-Ressource)