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Verfasst von:Lamas Murua, Miguel [VerfasserIn]   i
 Stolp-Rastätter, Bettina [VerfasserIn]   i
 Kaw, Sheetal [VerfasserIn]   i
 Thoma, Judith [VerfasserIn]   i
 Tsopoulidis, Nikolaos [VerfasserIn]   i
 Trautz, Birthe [VerfasserIn]   i
 Ambiel, Ina [VerfasserIn]   i
 Reif, Tatjana [VerfasserIn]   i
 Arora, Sakshi [VerfasserIn]   i
 Imle, Andrea [VerfasserIn]   i
 Tibroni, Nadine [VerfasserIn]   i
 Tanaka, Motomu [VerfasserIn]   i
 Fackler, Oliver Till [VerfasserIn]   i
Titel:HIV-1 Nef disrupts CD4+ T lymphocyte polarity, extravasation, and homing to lymph nodes via its nef-associated kinase complex interface
Verf.angabe:Miguel Lamas-Murua, Bettina Stolp, Sheetal Kaw, Judith Thoma, Nikolaos Tsopoulidis, Birthe Trautz, Ina Ambiel, Tatjana Reif, Sakshi Arora, Andrea Imle, Nadine Tibroni, Jingxia Wu, Guoliang Cui, Jens V. Stein, Motomu Tanaka, Ruth Lyck, Oliver T. Fackler
E-Jahr:2018
Jahr:26 September 2018
Umfang:13 S.
Fussnoten:Gesehen am 04.11.2019
Titel Quelle:Enthalten in: The journal of immunology
Ort Quelle:Bethesda, Md. : Soc., 1916
Jahr Quelle:2018
Band/Heft Quelle:201(2018), 9, Seite 2731-2743
ISSN Quelle:1550-6606
Abstract:HIV-1 Nef is a multifunctional protein that optimizes virus spread and promotes immune evasion of infected cells to accelerate disease progression in AIDS patients. As one of its activities, Nef reduces the motility of infected CD4+ T lymphocytes in confined space. In vivo, Nef restricts T lymphocyte homing to lymph nodes as it reduces the ability for extravasation at the diapedesis step. Effects of Nef on T lymphocyte motility are typically mediated by its ability to reduce actin remodeling. However, interference with diapedesis does not depend on residues in Nef required for inhibition of host cell actin dynamics. In search for an alternative mechanism by which Nef could alter T lymphocyte extravasation, we noted that the viral protein interferes with the polarization of primary human CD4+ T lymphocytes upon infection with HIV-1. Expression of Nef alone is sufficient to disrupt T cell polarization, and this effect is conserved among lentiviral Nef proteins. Nef acts by arresting the oscillation of CD4+ T cells between polarized and nonpolarized morphologies. Mapping studies identified the binding site for the Nef-associated kinase complex (NAKC) as critical determinant of this Nef activity and a NAKC-binding-deficient Nef variant fails to impair CD4+ T lymphocyte extravasation and homing to lymph nodes. These results thus imply the disruption of T lymphocyte polarity via its NAKC binding site as a novel mechanism by which lentiviral Nef proteins alter T lymphocyte migration in vivo.
DOI:doi:10.4049/jimmunol.1701420
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.4049/jimmunol.1701420
 Verlag: https://www.jimmunol.org/content/201/9/2731
 DOI: https://doi.org/10.4049/jimmunol.1701420
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1680889710
Verknüpfungen:→ Zeitschrift

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