Evaluation of the role of transhepatic flow in postoperative outcomes following major hepatectomy (THEFLOW)

• Verfasst von: Golriz, Mohammad [VerfasserIn]
• Verfasst von: Murtha-Lemekhova, Anastasia [VerfasserIn]
• Verfasst von: Khajeh, Elias [VerfasserIn]
• Verfasst von: Ghamarnejad, Omid [VerfasserIn]
• Verfasst von: Saeedi, Mohammed al [VerfasserIn]
• Verfasst von: Strobel, Oliver [VerfasserIn]
• Verfasst von: Hackert, Thilo [VerfasserIn]
• Verfasst von: Müller, Beat P. [VerfasserIn]
• Verfasst von: Schneider, Martin [VerfasserIn]
• Verfasst von: Berchtold, Christoph [VerfasserIn]
• Verfasst von: Tinoush, Parham [VerfasserIn]
• Verfasst von: Mayer, Philipp [VerfasserIn]
• Verfasst von: Chang, De-Hua [VerfasserIn]
• Verfasst von: Weiss, Karl Heinz [VerfasserIn]
• Verfasst von: Hoffmann, Katrin [VerfasserIn]
• Verfasst von: Mehrabi, Arianeb [VerfasserIn]
• Titel: Evaluation of the role of transhepatic flow in postoperative outcomes following major hepatectomy (THEFLOW)
• Titelzusatz: study protocol for a single-centre, non-interventional cohort study
• Verf.angabe: Mohammad Golriz, Anastasia Lemekhova, Elias Khajeh, Omid Ghamarnejad, Mohammed Al-Saeedi, Oliver Strobel, Hackert Thilo, Beat Müller-Stich, Martin Schneider, Christoph Berchtold, Parham Tinoush, Philipp Mayer, De-Hua Chang, Karl Heinz Weiss, Katrin Hoffmann, Arianeb Mehrabi
• E-Jahr: 2019
• Jahr: October 11, 2019
• Umfang: 7 S.
• Fussnoten: Gesehen am 05.11.2019
• Titel Quelle: Enthalten in: BMJ open
• Ort Quelle: London : BMJ Publishing Group, 2011
• Jahr Quelle: 2019
• Band/Heft Quelle: 9(2019), 10, Artikel-ID 029618, Seite 1-7
• ISSN Quelle: 2044-6055
• DOI: doi:10.1136/bmjopen-2019-029618
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: chemotherapy
• Sach-SW: major hepatectomy
• Sach-SW: small for size and flow syndrome
• Sach-SW: transhepatic flow
• K10plus-PPN: 1681027534

Abstract

Introduction Liver resection is the only curative treatment for primary and secondary hepatic tumours. Improvements in perioperative preparation of patients and new surgical developments have made complex liver resections possible. However, small for size and flow syndrome (SFSF) is still a challenging issue, rendering patients inoperable and causing postoperative morbidity and mortality. Although the role of transhepatic flow in the postoperative outcome has been shown in small partial liver transplantation and experimental studies of SFSF, this has never been studied in the clinical setting following liver resection. The aim of this study is to systematically evaluate transhepatic flow changes following major liver resection and its correlation with postoperative outcomes. - Methods and analysis The TransHEpatic FLOW (THEFLOW) study is a single-centre, non-interventional cohort study, and aims to enrol 50 patients undergoing major hepatectomy (defined as hemihepatectomy or extended hepatectomy based on the Brisbane classification) with or without prior chemotherapy. The portal venous flow, hepatic artery flow and portal venous pressure are measured before and after each resection. All patients are followed-up for 3 months after the operation. During each evaluation, standard clinical data, posthepatectomy liver failure and overall morbidity and mortality will be recorded. THEFLOW study was initiated on 25 March 2018 and is expected to progress for 2 years. - Ethics and dissemination This protocol study received approval from the Ethics Committee of the University of Heidelberg (registration number: S576/2017). The results of this study will be published in a peer-reviewed journal, and will also be presented at medical meetings. - Trial registration number NCT03762876.