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| Verfasst von: | Kahn, Nicolas [VerfasserIn]  |
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| | Rossler, Anne-Kathrin [VerfasserIn] |
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| | Hornemann, Katrin Emma [VerfasserIn] |
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| | Muley, Thomas [VerfasserIn] |
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| | Grünig, Ekkehard [VerfasserIn] |
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| | Schmidt, Werner [VerfasserIn] |
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| | Herth, Felix [VerfasserIn] |
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| | Kreuter, Michael [VerfasserIn] |
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| Titel: | C-proSP-B |
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| Titelzusatz: | a possible biomarker for pulmonary diseases? |
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| Verf.angabe: | Nicolas Kahn, Anne-Kathrin Rossler, Katrin Hornemann, Thomas Muley, Ekkehard Grünig, Werner Schmidt, Felix J.F. Herth, Michael Kreuter |
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| E-Jahr: | 2018 |
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| Jahr: | May 15,2018 |
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| Umfang: | 10 S. |
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| Teil: | volume:96 |
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| | year:2018 |
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| | number:2 |
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| | pages:117-126 |
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| | extent:10 |
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| Fussnoten: | Gesehen am 04.11.2019 |
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| Titel Quelle: | Enthalten in: Respiration |
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| Ort Quelle: | Basel : Karger, 1944 |
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| Jahr Quelle: | 2018 |
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| Band/Heft Quelle: | 96(2018), 2, Seite 117-126 |
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| ISSN Quelle: | 1423-0356 |
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| Abstract: | <b><i>Background:</i></b> Detection of surfactant proteins A and D (SP-A and SP-D) in the serum of patients with pulmonary diseases is thought to reflect an injury of the alveolar epithelial barrier and as such serve as a biomarker for these diseases. However, the data for SP-B are limited. <b><i>Objectives:</i></b> The aim of this feasibility study was to assess whether immature SP-B pre-proteins might have value as a possible biomarker for pulmonary diseases. <b><i>Methods:</i></b> In serum samples from patients with different chronic lung diseases (interstitial lung diseases [ILDs], chronic obstructive pulmonary disease, asthma, lung cancer, pulmonary hypertension, inflammation, patients on ventilator support; total <i>n</i> = 283), C-proSP-B was measured using an electrochemiluminescence immunoassay based on mouse monoclonal anti-C-proSP-B antibodies. Levels were correlated to lung functional and clinical parameters. <b><i>Results:</i></b> The highest C-proSP-B levels were detected in the serum of idiopathic pulmonary fibrosis (IPF) patients. In a multivariate analysis, C-proSP-B levels were able to discriminate IPF patients from patients with all other pulmonary diseases (<i>p</i> < 0.0001). No significant correlations were found between C-proSP-B levels and lung function, smoking history, or disease extent. <b><i>Conclusions:</i></b> SP-B pre-proteins might serve as a biomarker in pulmonary diseases with alveolar or interstitial damage such as ILDs, especially in IPF. Their role in the long-term monitoring of such diseases has to be clarified further. |
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| DOI: | doi:10.1159/000488245 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1159/000488245 |
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| | Volltext: https://www.karger.com/Article/FullText/488245 |
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| | DOI: https://doi.org/10.1159/000488245 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1681064952 |
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| Verknüpfungen: | → Zeitschrift |
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