Navigation überspringen
Universitätsbibliothek Heidelberg
Status: Bibliographieeintrag

Verfügbarkeit
Standort: ---
Exemplare: ---
heiBIB
 Online-Ressource
Verfasst von:Oras, Astrid [VerfasserIn]   i
 Giese, Thomas [VerfasserIn]   i
Titel:A study of 51 subtypes of peripheral blood immune cells in newly diagnosed young type 1 diabetes patients
Verf.angabe:A. Oras, A. Peet, T. Giese, V. Tillmann, R. Uibo
E-Jahr:2019
Jahr:22 May 2019
Umfang:14 S.
Fussnoten:Gesehen am 05.11.2019
Titel Quelle:Enthalten in: Clinical & experimental immunology
Ort Quelle:Oxford : Wiley-Blackwell, 1966
Jahr Quelle:2019
Band/Heft Quelle:198(2019), 1, Seite 57-70
ISSN Quelle:1365-2249
Abstract:Type 1 diabetes (T1D) results from autoimmune destruction of insulin-producing beta cells in pancreatic islets. Various immune cell populations are involved in disease development and natural course. However, to our knowledge, so far there are no comprehensive comparative investigations of all main immune cell populations and their most important subsets at the onset of disease. Therefore, in the current study, we analyzed 51 peripheral blood immune cell populations in 22 young T1D patients and in 25 age-matched controls using a comprehensive polychromatic flow cytometry panel developed for whole blood by the COST Action no. BM0907 ENTIRE (European Network for Translational Immunology Research and Education: From Immunomonitoring to Personalized Immunotherapy) consortium. We found that in T1D patients, frequencies and absolute counts of natural killer (NK) cells, dendritic cells (DC) and T cells, as well as their respective subsets, were significantly altered compared to controls. Further, we observed that changes in several cell populations (e.g. CD14+CD16+ non-classical monocytes, plasmablasts) were dependent on the age of the patient. In addition to age-related changes, we also found that alterations in immune cell patterns were associated with parameters such as the presence of ketoacidosis and C-peptide serum levels. Our study provides a foundation for future studies investigating different cell lineages and their role in T1D and illustrates the value of polychromatic flow cytometry for evaluating all main peripheral immune cells and their subsets in whole blood samples.
DOI:doi:10.1111/cei.13332
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: https://doi.org/10.1111/cei.13332
 Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/cei.13332
 DOI: https://doi.org/10.1111/cei.13332
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:autoimmunity
 cell surface molecules
 diabetes
 pancreas
K10plus-PPN:1681068575
Verknüpfungen:→ Zeitschrift

Permanenter Link auf diesen Titel (bookmarkfähig):  https://katalog.ub.uni-heidelberg.de/titel/68450357   QR-Code
zum Seitenanfang