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Verfasst von:Hüttner, Felix [VerfasserIn]   i
 Diener, Markus K. [VerfasserIn]   i
 Tarantino, Ignazio [VerfasserIn]   i
 Ulrich, Alexis [VerfasserIn]   i
Titel:Prognostic impact of anastomotic leakage after elective colon resection for cancer
Titelzusatz:a propensity score matched analysis of 628 patients
Verf.angabe:Felix J. Hüttner, Rene Warschkow, Bruno M. Schmied, Markus K. Diener, Ignazio Tarantino, Alexis Ulrich
E-Jahr:2018
Jahr:31 January 2018
Umfang:7 S.
Fussnoten:Gesehen am 07.11.2019
Titel Quelle:Enthalten in: European journal of surgical oncology
Ort Quelle:Burlington, Mass. : Harcourt, 1995
Jahr Quelle:2018
Band/Heft Quelle:44(2018), 4, Seite 456-462
ISSN Quelle:1532-2157
Abstract:Background - There is limited information regarding the impact of anastomotic leakage on oncologic outcome in exclusively colon cancer patients. - Methods - The colorectal database of the Department of Surgery of the University of Heidelberg was used to assess the impact of anastomotic leakage on oncologic outcome in patients undergoing curative resection for Stage I-III colon cancer. Risk-adjusted Cox regression analysis and propensity score methods were used to assess overall, disease-free, and relative survival. - Results - 628 patients of which 26 (4.1%) experienced anastomotic leakage were analysed. Anastomotic leakage was associated with significantly worse overall, disease-free and relative survival in univariate and multivariate analysis. The analysis after exact propensity score matching confirmed the negative impact of anastomotic leakage on overall (HR 2.62, 95% CI 1.33-5.18, p = .011), disease-free (HR 2.28, 95% CI 1.16-4.47, p = .027) and relative survival (HR 3.70, 95% CI 1.82-7.52, p < .001). 5-year overall survival was 51.6% (95% CI 34.5-77.2%) for patients with anastomotic leakage compared to 77.7% (95% CI 73.0-82.8%) for patients without anastomotic leakage. - Conclusions - All conceivable efforts should be made to avoid anastomotic leakage after colon resection for cancer not only to evade short-term consequences but also to allow for adequate long-term outcome.
DOI:doi:10.1016/j.ejso.2018.01.079
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1016/j.ejso.2018.01.079
 Volltext: http://www.sciencedirect.com/science/article/pii/S074879831830115X
 DOI: https://doi.org/10.1016/j.ejso.2018.01.079
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Anastomotic leakage
 Colon cancer
 Prognosis
 Survival
K10plus-PPN:1681408392
Verknüpfungen:→ Zeitschrift

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