Transdiagnostic dimensions of psychopathology at first episode psychosis

• Verfasst von: Quattrone, Diego [VerfasserIn]
• Verfasst von: Reininghaus, Ulrich [VerfasserIn]
• Titel: Transdiagnostic dimensions of psychopathology at first episode psychosis
• Titelzusatz: findings from the multinational EU-GEI study
• Verf.angabe: Diego Quattrone, Marta Di Forti, Charlotte Gayer-Anderson, Laura Ferraro, Hannah E Jongsma, Giada Tripoli, Caterina La Cascia, Daniele La Barbera, Ilaria Tarricone, Domenico Berardi, Andrei Szöke, Celso Arango, Antonio Lasalvia, Andrea Tortelli, Pierre-Michel Llorca, Lieuwe de Haan, Eva Velthorst, Julio Bobes, Miguel Bernardo, Julio Sanjuán, Jose Luis Santos, Manuel Arrojo, Cristina Marta Del-Ben, Paulo Rossi Menezes, Jean-Paul Selten, EU-GEI WP2 Group, Peter B Jones, James B Kirkbride, Alexander L Richards, Michael C O'Donovan, Pak C Sham, Evangelos Vassos, Bart PF Rutten, Jim van Os, Craig Morgan, Cathryn M Lewis, Robin M Murray and Ulrich Reininghaus
• Jahr: 2019
• Jahr des Originals: 2018
• Umfang: 14 S.
• Fussnoten: Published online by Cambridge University Press: 04 October 2018 ; Appendix non-author EU-GEI collaborators Kathryn Hubbard, Stephanie Beards, Simona A. Stilo, Mara Parellada, PedroCuadrado, José Juan Rodríguez Solano, Angel Carracedo, Enrique GarcíaBernardo, Laura Roldán, Gonzalo López, Bibiana Cabrera, EstherLorente-Rovira, Paz Garcia-Portilla, Javier Costas, Estela Jiménez-López,Mario Matteis, Marta Rapado, Emiliano González, Covadonga Martínez,Emilio Sánchez,MaSoledad Olmeda, Nathalie Franke, FabianTermorshuizen, Daniella van Dam, Elsje van der Ven, EllesMesschaart, Marion Leboyer, Franck Schürhoff, StéphaneJamain, Grégoire Baudin, Aziz Ferchiou, Baptiste Pignon,Jean-Romain Richard, Thomas Charpeaud, Anne-MarieTronche, Flora Frijda, Giovanna Marrazzo, Lucia Sideli,Crocettarachele Sartorio, Fabio Seminerio, Camila MarcelinoLoureiro, Rosana Shuhama, Mirella Ruggeri, Sarah Tosato, ChiaraBonetto and Doriana Cristofalo26 ; Gesehen am 07.11.2019
• Titel Quelle: Enthalten in: Psychological medicine
• Ort Quelle: Cambridge : Cambridge Univ. Press, 1970
• Jahr Quelle: 2019
• Band/Heft Quelle: 49(2019), 8, Seite 1378-1391
• ISSN Quelle: 1469-8978
• DOI: doi:10.1017/S0033291718002131
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1681420287

Abstract

Method. This study included 2182 FEP individuals recruited across six countries, as part of the EUropean network of national schizophrenia networks studying Gene-Environment Interactions (EU-GEI) study. Symptom ratings were analysed using multidimensional item response modelling in Mplus to estimate five theory-based models of psychosis. We used multiple regression models to examine demographic and context factors associated with symptom dimensions. - Results. A bifactor model, composed of one general factor and five specific dimensions of positive, negative, disorganization, manic and depressive symptoms, best-represented associations among ratings of psychotic symptoms. Positive symptoms were more common in ethnic minority groups. Urbanicity was associated with a higher score on the general factor. Men presented with more negative and less depressive symptoms than women. Early age-at-firstcontact with psychiatric services was associated with higher scores on negative, disorganized, and manic symptom dimensions. - Conclusions. Our results suggest that the bifactor model of psychopathology holds across diagnostic categories of non-affective and affective psychosis at FEP, and demographic and context determinants map onto general and specific symptom dimensions. These findings have implications for tailoring symptom-specific treatments and inform research into the mood-psychosis spectrum.