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| Verfasst von: | Jungi, Silvan [VerfasserIn]  |
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| | Fu, X. [VerfasserIn] |
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| | Segiser, A. [VerfasserIn] |
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| | Busch, Martin [VerfasserIn] |
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| | Most, Patrick [VerfasserIn] |
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| | Fiedler, M. [VerfasserIn] |
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| | Carrel, T. [VerfasserIn] |
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| | Tevaearai Stahel, H. [VerfasserIn] |
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| | Longnus, S. L. [VerfasserIn] |
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| | Most, Henriette [VerfasserIn] |
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| Titel: | Enhanced cardiac S100A1 expression improves recovery from Gglobal Ischemia-reperfusion injury |
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| Verf.angabe: | S. Jungi, X. Fu, A. Segiser, M. Busch, P. Most, M. Fiedler, T. Carrel, H. Tevaearai Stahel, S.L. Longnus, Henriette Most |
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| E-Jahr: | 2018 |
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| Jahr: | 1 February 2018 |
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| Umfang: | 10 S. |
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| Fussnoten: | Gesehen am 07.11.2019 |
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| Titel Quelle: | Enthalten in: Journal of cardiovascular translational research |
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| Ort Quelle: | New York, NY [u.a.] : Springer, 2008 |
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| Jahr Quelle: | 2018 |
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| Band/Heft Quelle: | 11(2018), 3, Seite 236-245 |
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| ISSN Quelle: | 1937-5395 |
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| Abstract: | Gene-targeted therapy with the inotropic Ca2 + -sensor protein S100A1 rescues contractile function in post-ischemic heart failure and is being developed towards clinical trials. Its proven beneficial effect on cardiac metabolism and mitochondrial function suggests a cardioprotective effect of S100A1 in myocardial ischemia-reperfusion injury (IRI). Fivefold cardiomyocyte-specific S100A1 overexpressing, isolated rat hearts perfused in working mode were subjected to 28 min ischemia (37 °C) followed by 60 min reperfusion. S100A1 overexpressing hearts showed superior hemodynamic recover: Left ventricular pressure recovered to 57 ± 7.3% of baseline compared to 51 ± 4.6% in control (p = 0.025), this effect mirrored in LV work and dP/dt(max). Troponin T and lactate dehydrogenase was decreased in the S100A1 group, as well as FoxO pro-apoptotic transcription factor, indicating less tissue necrosis, whereas phosphocreatine content was higher after reperfusion. This is the first report of a cardioprotective effect of S100A1 overexpression in a global IRI model. |
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| DOI: | doi:10.1007/s12265-018-9788-y |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1007/s12265-018-9788-y |
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| | DOI: https://doi.org/10.1007/s12265-018-9788-y |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Cardioprotection |
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| | Inotropic therapy |
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| | Ischemia-reperfusion injury |
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| | S100A1 |
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| K10plus-PPN: | 1681429217 |
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| Verknüpfungen: | → Zeitschrift |
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Enhanced cardiac S100A1 expression improves recovery from Gglobal Ischemia-reperfusion injury / Jungi, Silvan [VerfasserIn]; 1 February 2018 (Online-Ressource)
