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Verfasst von:Kranaster, Laura [VerfasserIn]   i
 Hellweg, Rainer [VerfasserIn]   i
 Sartorius, Alexander [VerfasserIn]   i
Titel:Association between the novel seizure quality index for the outcome prediction in electroconvulsive therapy and brain-derived neurotrophic factor serum levels
Verf.angabe:Laura Kranaster, Rainer Hellweg, Alexander Sartorius
E-Jahr:2019
Jahr:09 April 2019
Umfang:5 S.
Fussnoten:Gesehen am 08.11.2019
Titel Quelle:Enthalten in: Neuroscience letters
Ort Quelle:Amsterdam [u.a.] : Elsevier Science, 1975
Jahr Quelle:2019
Band/Heft Quelle:704(2019), Seite 164-168
ISSN Quelle:1872-7972
Abstract:The novel Seizure Quality Index (SQI) could predict the risk of non-response and non-remission as early as after the second electroconvulsive therapy (ECT) session based the extent of several ictal parameters of the seizure in patients with depression. The association between those indices with the peripheral serum levels of brain-derived neurotrophic factor (BDNF) was evaluated in this study. It was proposed that seizure quality reflected by the SQI will be positively correlated with the levels of serum BDNF after ECT in patients with depression. We included 36 patients with a full data set, a completed course of ECT and BDNF levels before and after that ECT course. Baseline serum BDNF levels (2838.9 pg/ml ±1659.9) were lower compared to the mean BDNF levels after ECT (3206.3 pg/ml ±1532.3), but the statistical test did not reach significance (z = 1.96, p = 0.051, r = 0.23). In a sub-group analysis, the BDNF levels after ECT were positively correlated with the SQI sum score for response (rs = 0.62, p = 0.018) and for remission (rs = 0.57, p = 0.033) in patients younger than 65 years, the group, for whom the SQI has been built and validated. This suggests that one link between seizure quality and antidepressant response to ECT could be BDNF.
DOI:doi:10.1016/j.neulet.2019.04.023
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1016/j.neulet.2019.04.023
 Verlag: http://www.sciencedirect.com/science/article/pii/S0304394019302575
 DOI: https://doi.org/10.1016/j.neulet.2019.04.023
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Brain-derived neurotrophic factor
 Depression
 Electroconvulsive therapy
 Outcome
K10plus-PPN:1681492067
Verknüpfungen:→ Zeitschrift

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