Regulation of gene expression in trypanosomatids

• Verfasst von: Clayton, Christine [VerfasserIn]
• Titel: Regulation of gene expression in trypanosomatids
• Titelzusatz: living with polycistronic transcription
• Verf.angabe: Christine Clayton
• E-Jahr: 2019
• Jahr: 05 June 2019
• Umfang: 24 S.
• Fussnoten: Gesehen am 08.11.2019
• Titel Quelle: Enthalten in: Open biology
• Ort Quelle: London : Royal Society Publishing, 2010
• Jahr Quelle: 2019
• Band/Heft Quelle: 9(2019,6) Artikel-Nummer 190072, 24 Seiten
• ISSN Quelle: 2046-2441
• DOI: doi:10.1098/rsob.190072
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1681506661

Abstract

In trypanosomes, RNA polymerase II transcription is polycistronic and individual mRNAs are excised by trans-splicing and polyadenylation. The lack of individual gene transcription control is compensated by control of mRNA processing, translation and degradation. Although the basic mechanisms of mRNA decay and translation are evolutionarily conserved, there are also unique aspects, such as the existence of six cap-binding translation initiation factor homologues, a novel decapping enzyme and an mRNA stabilizing complex that is recruited by RNA-binding proteins. High-throughput analyses have identified nearly a hundred regulatory mRNA-binding proteins, making trypanosomes valuable as a model system to investigate post-transcriptional regulation.