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Status: Bibliographieeintrag

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Verfasst von:Gülmez Karaca, Kübra [VerfasserIn]   i
 Zeuch, Benjamin [VerfasserIn]   i
 Oliveira, Ana [VerfasserIn]   i
Titel:Adult hippocampal MeCP2 preserves the genomic responsiveness to learning required for long-term memory formation
Verf.angabe:Kubra Gulmez Karaca, David V.C. Brito, Benjamin Zeuch, Ana M.M. Oliveira
E-Jahr:2018
Jahr:10 February 2018
Umfang:14 S.
Fussnoten:Gesehen am 11.11.2019
Titel Quelle:Enthalten in: Neurobiology of learning and memory
Ort Quelle:Orlando, Fla. : Academic Press, 1995
Jahr Quelle:2018
Band/Heft Quelle:149(2018), Seite 84-97
ISSN Quelle:1095-9564
Abstract:MeCP2 is required both during postnatal neurodevelopment and throughout the adult life for brain function. Although it is well accepted that MeCP2 in the maturing nervous system is critical for establishing normal development, the functions of MeCP2 during adulthood are poorly understood. Particularly, the requirement of hippocampal MeCP2 for cognitive abilities in the adult is not studied. To characterize the role of MeCP2 in adult neuronal function and cognition, we used a temporal and region-specific disruption of MeCP2 expression in the hippocampus of adult male mice. We found that MeCP2 is required for long-term memory formation and that it controls the learning-induced transcriptional response of hippocampal neurons required for memory consolidation. Furthermore, we uncovered MeCP2 functions in the adult hippocampus that may underlie cognitive integrity. We showed that MeCP2 maintains the developmentally established chromatin configuration and epigenetic landscape of CA1 neurons throughout the adulthood, and that it regulates the expression of neuronal and immune-related genes in the adult hippocampus. Overall, our findings identify MeCP2 as a maintenance factor in the adult hippocampus that preserves signal responsiveness of the genome and allows for integrity of cognitive functions. This study provides new insight into how MeCP2 maintains adult brain functions, but also into the mechanisms underlying the cognitive impairments observed in RTT patients and highlights the understudied role of DNA methylation interpretation in adult cognitive processes.
DOI:doi:10.1016/j.nlm.2018.02.010
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1016/j.nlm.2018.02.010
 Verlag: http://www.sciencedirect.com/science/article/pii/S1074742718300297
 DOI: https://doi.org/10.1016/j.nlm.2018.02.010
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Adult brain
 Chromatin structure
 DNA methylation
 Hippocampus-dependent memory
 Plasticity-related genes
 Rett syndrome
K10plus-PPN:1681558467
Verknüpfungen:→ Zeitschrift

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