Adamantinomatous and papillary craniopharyngiomas are characterized by distinct epigenomic as well as mutational and transcriptomic profiles

• Verfasst von: Hölsken, Annett [VerfasserIn]
• Verfasst von: Sill, Martin [VerfasserIn]
• Verfasst von: Pfister, Stefan [VerfasserIn]
• Verfasst von: Deimling, Andreas von [VerfasserIn]
• Verfasst von: Capper, David [VerfasserIn]
• Verfasst von: Jones, David T. W. [VerfasserIn]
• Titel: Adamantinomatous and papillary craniopharyngiomas are characterized by distinct epigenomic as well as mutational and transcriptomic profiles
• Verf.angabe: Annett Hölsken, Martin Sill, Jessica Merkle, Leonille Schweizer, Michael Buchfelder, Jörg Flitsch, Rudolf Fahlbusch, Markus Metzler, Marcel Kool, Stefan M. Pfister, Andreas von Deimling, David Capper, David T.W. Jones and Rolf Buslei
• E-Jahr: 2016
• Jahr: 29 February 2016
• Umfang: 13 S.
• Fussnoten: Gesehen am 11.11.2019
• Titel Quelle: Enthalten in: Acta Neuropathologica Communications
• Ort Quelle: London : Biomed Central, 2013
• Jahr Quelle: 2016
• Band/Heft Quelle: 4(2016), Artikel-ID 20, Seite 1-13
• ISSN Quelle: 2051-5960
• DOI: doi:10.1186/s40478-016-0287-6
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1681581337

Abstract

Craniopharyngiomas (CP) are rare epithelial tumors of the sellar region. Two subtypes, adamantinomatous (adaCP) and papillary CP (papCP), were previously identified based on histomorphological and epidemiological aspects. Recent data indicates that both variants are defined by specific genetic alterations, and influenced by distinct molecular pathways and particular origins. The fact that CP is an uncommon tumor entity renders studies on large cohorts difficult and exceptional. In order to achieve further insights distinguishing CP variants, we conducted whole genome methylation (450 k array) and microarray-based gene expression studies in addition to CTNNB1 and BRAF mutation analysis using a comprehensive cohort of 80 adaCP and 35 papCP.