Distal pancreatectomy with celiac axis resection (DP-CAR) for pancreatic cancer

• Verfasst von: Klompmaker, Sjors [VerfasserIn]
• Verfasst von: Hackert, Thilo [VerfasserIn]
• Titel: Distal pancreatectomy with celiac axis resection (DP-CAR) for pancreatic cancer
• Titelzusatz: how I do it
• Verf.angabe: Sjors Klompmaker, Ugo Boggi, Thilo Hackert, Roberto Salvia, Matthew Weiss, Hiroki Yamaue, Herbert J. Zeh, Marc G. Besselink
• E-Jahr: 2018
• Jahr: 13 August 2018
• Umfang: 7 S.
• Fussnoten: Gesehen am 11.11.2019
• Titel Quelle: Enthalten in: Journal of gastrointestinal surgery
• Ort Quelle: New York, NY : Springer, 1997
• Jahr Quelle: 2018
• Band/Heft Quelle: 22(2018), 10, Seite 1804-1810
• ISSN Quelle: 1873-4626
• DOI: doi:10.1007/s11605-018-3894-7
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Appleby
• Sach-SW: Cancer
• Sach-SW: DP-CAR
• Sach-SW: High volume
• Sach-SW: Ischemia
• Sach-SW: Morbidity
• Sach-SW: Mortality
• Sach-SW: Pancreas
• Sach-SW: Pancreas surgery
• Sach-SW: Pancreatic cancer
• Sach-SW: Pancreatic fistula
• Sach-SW: Survival
• Sach-SW: Technique
• K10plus-PPN: 1681582902

Abstract

Approximately 30% of all pancreatic cancer patients have locally advanced (AJCC stage 3) disease. A sub-group of these patients - where the cancer only involves the celiac axis - may benefit from distal pancreatectomy with celiac axis resection (DP-CAR). Previous studies have shown that DP-CAR offers a survival benefit to a selected group of patients with otherwise unresectable pancreatic cancer, when performed by experienced pancreatic cancer treatment teams at high-volume centers. This article proposes a standardized approach to DP-CAR, including routine neoadjuvant (FOLFIRINOX) chemotherapy. This approach to selecting patients and performing DP-CAR has the potential to improve short-term outcomes and overall survival in selected patients, but it should be reserved for high-volume centers.