| |  Online-Ressource |
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| Verfasst von: | Islinger, Markus [VerfasserIn]  |
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| | Völkl, Alfred [VerfasserIn] |
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| | Fahimi, H. Dariush [VerfasserIn] |
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| | Schrader, Michael [VerfasserIn] |
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| Titel: | The peroxisome |
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| Titelzusatz: | an update on mysteries 2.0 |
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| Verf.angabe: | Markus Islinger, Alfred Voelkl, H. Dariush Fahimi, Michael Schrader |
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| E-Jahr: | 2018 |
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| Jahr: | 15 September 2018 |
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| Umfang: | 29 S. |
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| Fussnoten: | Gesehen am 12.11.2019 |
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| Titel Quelle: | Enthalten in: Histochemistry and cell biology |
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| Ort Quelle: | Berlin : Springer, 1958 |
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| Jahr Quelle: | 2018 |
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| Band/Heft Quelle: | 150(2018), 5, Seite 443-471 |
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| ISSN Quelle: | 1432-119X |
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| Abstract: | Peroxisomes are key metabolic organelles, which contribute to cellular lipid metabolism, e.g. the β-oxidation of fatty acids and the synthesis of myelin sheath lipids, as well as cellular redox balance. Peroxisomal dysfunction has been linked to severe metabolic disorders in man, but peroxisomes are now also recognized as protective organelles with a wider significance in human health and potential impact on a large number of globally important human diseases such as neurodegeneration, obesity, cancer, and age-related disorders. Therefore, the interest in peroxisomes and their physiological functions has significantly increased in recent years. In this review, we intend to highlight recent discoveries, advancements and trends in peroxisome research, and present an update as well as a continuation of two former review articles addressing the unsolved mysteries of this astonishing organelle. We summarize novel findings on the biological functions of peroxisomes, their biogenesis, formation, membrane dynamics and division, as well as on peroxisome-organelle contacts and cooperation. Furthermore, novel peroxisomal proteins and machineries at the peroxisomal membrane are discussed. Finally, we address recent findings on the role of peroxisomes in the brain, in neurological disorders, and in the development of cancer. |
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| DOI: | doi:10.1007/s00418-018-1722-5 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1007/s00418-018-1722-5 |
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| | DOI: https://doi.org/10.1007/s00418-018-1722-5 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | ACBD5 |
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| | Alzheimer |
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| | Cancer |
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| | Hearing loss |
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| | Membrane contact sites |
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| | Motility |
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| | Multiple sclerosis |
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| | Organelle biogenesis |
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| | Organelle division |
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| | Organelle dynamics |
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| | Parkinson |
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| | Peroxin |
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| | Peroxisome |
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| K10plus-PPN: | 1681642603 |
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| Verknüpfungen: | → Zeitschrift |
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¬The¬ peroxisome / Islinger, Markus [VerfasserIn]; 15 September 2018 (Online-Ressource)
