Status: Bibliographieeintrag
Standort: ---
Exemplare:
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| Online-Ressource |
Verfasst von: | Lorenzi, Tommaso [VerfasserIn]  |
| Marciniak-Czochra, Anna [VerfasserIn]  |
| Stiehl, Thomas [VerfasserIn]  |
Titel: | A structured population model of clonal selection in acute leukemias with multiple maturation stages |
Verf.angabe: | Tommaso Lorenzi, Anna Marciniak-Czochra, Thomas Stiehl |
E-Jahr: | 2019 |
Jahr: | 26 July 2019 |
Umfang: | 35 S. |
Fussnoten: | Gesehen am 12.11.2019 |
Titel Quelle: | Enthalten in: Journal of mathematical biology |
Ort Quelle: | Berlin : Springer, 1974 |
Jahr Quelle: | 2019 |
Band/Heft Quelle: | 79(2019), 5, Seite 1587-1621 |
ISSN Quelle: | 1432-1416 |
Abstract: | Recent progress in genetic techniques has shed light on the complex co-evolution of malignant cell clones in leukemias. However, several aspects of clonal selection still remain unclear. In this paper, we present a multi-compartmental continuously structured population model of selection dynamics in acute leukemias, which consists of a system of coupled integro-differential equations. Our model can be analysed in a more efficient way than classical models formulated in terms of ordinary differential equations. Exploiting the analytical tractability of this model, we investigate how clonal selection is shaped by the self-renewal fraction and the proliferation rate of leukemic cells at different maturation stages. We integrate analytical results with numerical solutions of a calibrated version of the model based on real patient data. In summary, our mathematical results formalise the biological notion that clonal selection is driven by the self-renewal fraction of leukemic stem cells and the clones that possess the highest value of this parameter are ultimately selected. Moreover, we demonstrate that the self-renewal fraction and the proliferation rate of non-stem cells do not have a substantial impact on clonal selection. Taken together, our results indicate that interclonal variability in the self-renewal fraction of leukemic stem cells provides the necessary substrate for clonal selection to act upon. |
DOI: | doi:10.1007/s00285-019-01404-w |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1007/s00285-019-01404-w |
| DOI: https://doi.org/10.1007/s00285-019-01404-w |
Datenträger: | Online-Ressource |
Sprache: | eng |
Sach-SW: | 35B40 |
| 35Q92 |
| 35R09 |
| Acute leukemia |
| Asymptotic analysis |
| Clonal selection |
| Continuously structured population models |
| Integro-differential equations |
K10plus-PPN: | 1681676109 |
Verknüpfungen: | → Zeitschrift |
¬A¬ structured population model of clonal selection in acute leukemias with multiple maturation stages / Lorenzi, Tommaso [VerfasserIn]; 26 July 2019 (Online-Ressource)
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