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Status: Bibliographieeintrag

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Verfasst von:Lorenzi, Tommaso [VerfasserIn]   i
 Marciniak-Czochra, Anna [VerfasserIn]   i
 Stiehl, Thomas [VerfasserIn]   i
Titel:A structured population model of clonal selection in acute leukemias with multiple maturation stages
Verf.angabe:Tommaso Lorenzi, Anna Marciniak-Czochra, Thomas Stiehl
E-Jahr:2019
Jahr:26 July 2019
Umfang:35 S.
Fussnoten:Gesehen am 12.11.2019
Titel Quelle:Enthalten in: Journal of mathematical biology
Ort Quelle:Berlin : Springer, 1974
Jahr Quelle:2019
Band/Heft Quelle:79(2019), 5, Seite 1587-1621
ISSN Quelle:1432-1416
Abstract:Recent progress in genetic techniques has shed light on the complex co-evolution of malignant cell clones in leukemias. However, several aspects of clonal selection still remain unclear. In this paper, we present a multi-compartmental continuously structured population model of selection dynamics in acute leukemias, which consists of a system of coupled integro-differential equations. Our model can be analysed in a more efficient way than classical models formulated in terms of ordinary differential equations. Exploiting the analytical tractability of this model, we investigate how clonal selection is shaped by the self-renewal fraction and the proliferation rate of leukemic cells at different maturation stages. We integrate analytical results with numerical solutions of a calibrated version of the model based on real patient data. In summary, our mathematical results formalise the biological notion that clonal selection is driven by the self-renewal fraction of leukemic stem cells and the clones that possess the highest value of this parameter are ultimately selected. Moreover, we demonstrate that the self-renewal fraction and the proliferation rate of non-stem cells do not have a substantial impact on clonal selection. Taken together, our results indicate that interclonal variability in the self-renewal fraction of leukemic stem cells provides the necessary substrate for clonal selection to act upon.
DOI:doi:10.1007/s00285-019-01404-w
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1007/s00285-019-01404-w
 DOI: https://doi.org/10.1007/s00285-019-01404-w
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:35B40
 35Q92
 35R09
 Acute leukemia
 Asymptotic analysis
 Clonal selection
 Continuously structured population models
 Integro-differential equations
K10plus-PPN:1681676109
Verknüpfungen:→ Zeitschrift

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