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Status: Bibliographieeintrag

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Verfasst von:Ulrich, Cornelia [VerfasserIn]   i
 Gigić, Biljana [VerfasserIn]   i
 Böhm, Jürgen [VerfasserIn]   i
 Ose, Jennifer [VerfasserIn]   i
 Viskochil, Richard [VerfasserIn]   i
 Schneider, Martin [VerfasserIn]   i
 Colditz, Graham A. [VerfasserIn]   i
 Figueiredo, Jane C. [VerfasserIn]   i
 Grady, William M. [VerfasserIn]   i
 Li, Christopher I. [VerfasserIn]   i
 Shibata, David [VerfasserIn]   i
 Siegel, Erin M. [VerfasserIn]   i
 Toriola, Adetunji T. [VerfasserIn]   i
 Ulrich, Alexis [VerfasserIn]   i
Titel:The ColoCare study
Titelzusatz:a paradigm of transdisciplinary science in colorectal cancer outcomes
Verf.angabe:Cornelia M. Ulrich, Biljana Gigic, Jürgen Böhm, Jennifer Ose, Richard Viskochil, Martin Schneider, Graham A. Colditz, Jane C. Figueiredo, William M. Grady, Christopher I. Li, David Shibata, Erin M. Siegel, Adetunji T. Toriola, and Alexis Ulrich
Jahr:2019
Jahr des Originals:2018
Umfang:11 S.
Fussnoten:Published online 6 December 2018 ; Gesehen am 12.11.2019
Titel Quelle:Enthalten in: Cancer epidemiology, biomarkers & prevention
Ort Quelle:Philadelphia, Pa. : AACR, 1991
Jahr Quelle:2019
Band/Heft Quelle:28(2019), 3, Seite 591-601
ISSN Quelle:1538-7755
Abstract:Background: Colorectal cancer is a leading cause of cancer death. Biomarkers to predict treatment outcomes are needed, as is evidence whether postdiagnosis diet and lifestyle can affect well-being and clinical outcomes. The international ColoCare Consortium aims to identify new biologic markers (e.g., metabolomic, transcriptomic, metagenomic, genetic, epigenetic, proteomic markers) that predict clinical outcomes, and to characterize associations between modifiable risk factors (e.g., diet, supplement use, physical activity) with short-term and long-term patient-reported and clinical outcomes among patients with colorectal cancer.Methods/Results: ColoCare is recruiting newly diagnosed patients with colorectal cancer across six sites in the United States and one site in Germany. As of April 2018, we have recruited >2,000 patients across all sites. Our projected enrollment is >4,000 multiethnic patients with colorectal cancer. The study includes uniformly collected, comprehensive sets of data and biospecimens at multiple time points up to 5 years after diagnosis. Treatment and clinical data are abstracted from medical records and centrally harmonized. Biospecimens are archived according to standardized procedures. Our initial studies demonstrated metabolic differences in adipose tissue types. We further reported on associations of biological factors (e.g., inflammation, DNA methylation, metabolomics) with lifestyle factors (e.g., adiposity, smoking, physical activity, dietary supplement use) or joint associations with clinical outcomes. - Conclusions: ColoCare is a consortium for the investigation of multilevel factors relevant to colorectal cancer survivorship. - Impact: The combination of a comprehensive set of biospecimens collected at multiple time points, jointly with detailed assessments of health behaviors and other prognostic factors, results in a unique resource that facilitates wide-ranging, innovative, and impactful research on colorectal cancer.
DOI:doi:10.1158/1055-9965.EPI-18-0773
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: https://doi.org/10.1158/1055-9965.EPI-18-0773
 Volltext: https://cebp.aacrjournals.org/content/28/3/591
 DOI: https://doi.org/10.1158/1055-9965.EPI-18-0773
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1681679434
Verknüpfungen:→ Zeitschrift

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