Stimulated echo double diffusion encoded imaging of closed pores

• Verfasst von: Demberg, Kerstin [VerfasserIn]
• Verfasst von: Laun, Frederik Bernd [VerfasserIn]
• Verfasst von: Bachert, Peter [VerfasserIn]
• Verfasst von: Ladd, Mark E. [VerfasserIn]
• Verfasst von: Kuder, Tristan Anselm [VerfasserIn]
• Titel: Stimulated echo double diffusion encoded imaging of closed pores
• Titelzusatz: influence and removal of unbalanced terms
• Verf.angabe: Kerstin Demberg, Frederik Bernd Laun, Peter Bachert, Mark Edward Ladd, and Tristan Anselm Kuder
• E-Jahr: 2019
• Jahr: 15 October 2019
• Umfang: 12 S.
• Illustrationen: Illustrationen
• Fussnoten: Gesehen am 13.11.2019
• Titel Quelle: Enthalten in: Physical review
• Ort Quelle: Woodbury, NY : Inst., 2016
• Jahr Quelle: 2019
• Band/Heft Quelle: 100(2019,4) Artikel-Nummer 042408, Seite 1-12, 12 Seiten
• ISSN Quelle: 2470-0053
• DOI: doi:10.1103/PhysRevE.100.042408
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1681753855

Abstract

Nuclear magnetic resonance (NMR) diffusion pore imaging has been proposed to study the shape of arbitrary closed pores filled with an NMR-detectable medium by use of nonclassical diffusion encoding schemes. Potential applications can be found in biomedical imaging and porous media research. When studying non-point-symmetric pores, NMR signals with nonvanishing imaginary parts arise containing the pore shape information, which is lost for classical diffusion encoding schemes. Key limitations are the required high magnetic field gradient amplitudes and T2 relaxation while approaching the diffusion long-time limit. To benefit from the slower T1 decay, we demonstrate the feasibility of diffusion pore imaging with stimulated echoes using Monte Carlo simulations and experiments with hyperpolarized xenon-129 gas in well-defined geometries and show that the necessary complex-valued signals can be acquired. Analytical derivation of the stimulated echo double diffusion encoded signal was performed to investigate the effect of the additionally arising undesired terms on the complex phase information. These terms correspond to signals arising for spin-echo sequences with unbalanced gradients. For most possible applications, the unbalanced terms can be neglected. If non-negligible, selection of the appropriate signal component using a phase cycling scheme was demonstrated experimentally. Using stimulated echoes may be a step towards application of diffusion pore imaging to larger pores with gradient amplitudes available today in preclinical systems.