Status: Bibliographieeintrag
Standort: ---
Exemplare:
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| Online-Ressource |
Verfasst von: | Inoue, Daigo [VerfasserIn]  |
| Wittbrodt, Joachim [VerfasserIn]  |
| Gruss, Oliver [VerfasserIn]  |
Titel: | Loss and rebirth of the animal microtubule organizing center |
Titelzusatz: | how maternal expression of centrosomal proteins cooperates with the sperm centriole in zygotic centrosome reformation |
Verf.angabe: | Daigo Inoue, Joachim Wittbrodt, Oliver J. Gruss |
E-Jahr: | 2018 |
Jahr: | 09 March 2018 |
Umfang: | 9 S. |
Teil: | volume:40 |
| year:2018 |
| number:4 |
| extent:9 |
Fussnoten: | Gesehen am 18.11.2019 |
Titel Quelle: | Enthalten in: Bioessays |
Ort Quelle: | New York, NY : Wiley-Liss, 1984 |
Jahr Quelle: | 2018 |
Band/Heft Quelle: | 40(2018,4) Artikel-Nummer p1700135, 9 Seiten |
ISSN Quelle: | 1521-1878 |
Abstract: | Centrosomes are the main microtubule organizing centers in animal cells. In particular during embryogenesis, they ensure faithful spindle formation and proper cell divisions. As metazoan centrosomes are eliminated during oogenesis, they have to be reassembled upon fertilization. Most metazoans use the sperm centrioles as templates for new centrosome biogenesis while the egg's cytoplasm re-prepares all components for on-going centrosome duplication in rapidly dividing embryonic cells. We discuss our knowledge and the experimental challenges to analyze zygotic centrosome reformation, which requires genetic experiments to enable scrutinizing respective male and female contributions. Male and female knockout animals and mRNA injection to mimic maternal expression of centrosomal proteins could point a way to the systematic molecular dissection of the process. The most recent data suggest that timely expression of centrosome components in oocytes is the key to zygotic centrosome reformation that uses male sperm as coordinators for de novo centrosome production. |
DOI: | doi:10.1002/bies.201700135 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag ; Resolving-System: https://doi.org/10.1002/bies.201700135 |
| Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/bies.201700135 |
| DOI: https://doi.org/10.1002/bies.201700135 |
Datenträger: | Online-Ressource |
Sprache: | eng |
Sach-SW: | centriolar satellites |
| centriole |
| centrosome |
| fertilization |
| oocyte |
| pericentriolar material |
| sperm |
K10plus-PPN: | 1682033414 |
Verknüpfungen: | → Zeitschrift |
Loss and rebirth of the animal microtubule organizing center / Inoue, Daigo [VerfasserIn]; 09 March 2018 (Online-Ressource)
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