| Online-Ressource |
Verfasst von: | Hubertus, Simon Ralph [VerfasserIn]  |
| Thomas, Sebastian [VerfasserIn]  |
| Cho, Junghun [VerfasserIn]  |
| Zhang, Shun [VerfasserIn]  |
| Wang, Yi [VerfasserIn]  |
| Schad, Lothar R. [VerfasserIn]  |
Titel: | Comparison of gradient echo and gradient echo sampling of spin echo sequence for the quantification of the oxygen extraction fraction from a combined quantitative susceptibility mapping and quantitative BOLD (QSM+qBOLD) approach |
Verf.angabe: | Simon Hubertus, Sebastian Thomas, Junghun Cho, Shun Zhang, Yi Wang, Lothar Rudi Schad |
E-Jahr: | 2019 |
Jahr: | 02 June 2019 |
Umfang: | 13 S. |
Fussnoten: | Gesehen am 19.11.2019 |
Titel Quelle: | Enthalten in: Magnetic resonance in medicine |
Ort Quelle: | New York, NY [u.a.] : Wiley-Liss, 1984 |
Jahr Quelle: | 2019 |
Band/Heft Quelle: | 82(2019), 4, Seite 1491-1503 |
ISSN Quelle: | 1522-2594 |
Abstract: | Purpose To compare gradient echo (GRE) and gradient echo sampling of spin echo (GESSE) sequences for the quantification of the oxygen extraction fraction (OEF) from combined quantitative BOLD and quantitative susceptibility mapping (QSM) with regard to accuracy, precision and parameter initialization. Methods GRE and GESSE data were acquired from 7 healthy volunteers. QSM was applied to the GRE data and used as a regularization for the single-compartment quantitative BOLD fit to the GESSE and GRE data, respectively, to quantify OEF, deoxygenated blood volume (ν), R2, and non-blood susceptibility (χnb). Intersubject means within gray and white matter, respectively, were compared between GESSE and GRE (Student's t) and gray-white matter contrast was determined for each sequence separately. A single- and multi-compartment simulation was used to compare reconstruction accuracy. Results Intersubject means and SDs for gray and white matter were OEF = 32.4 ± 1.6%, ν = 2.9 ± 0.1%, R2 = 14.2 ± 0.5 Hz, χnb = −43 ± 5 ppb for GESSE and OEF = 43.0 ± 5.4%, ν = 3.5 ± 0.4%, R2 = 14.4 ± 0.7 Hz, χnb = −43 ± 8 ppb for GRE with a significant difference (P < 0.05) for OEF and ν. Gray-white matter contrast was significant (P < 0.05) in all parameters for GESSE but only in ν and R2 for GRE. All parameters reconstructed from GESSE had higher accuracy than from GRE in the single- but not multi-compartment simulation. Conclusion GESSE yields higher parameter accuracy in simulated gray matter but produces unphysiological gray-white matter contrast in OEF in vivo. GRE produces uniform OEF maps in vivo and is more efficient, which could facilitate a clinical implementation, but revealed biases in simulation. The appropriate sequence should be chosen depending on application. |
DOI: | doi:10.1002/mrm.27804 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1002/mrm.27804 |
| Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/mrm.27804 |
| DOI: https://doi.org/10.1002/mrm.27804 |
Datenträger: | Online-Ressource |
Sprache: | eng |
Sach-SW: | GESSE |
| GRE |
| oxygen extraction fraction |
| quantitative BOLD |
| quantitative susceptibility mapping |
K10plus-PPN: | 1682125688 |
Verknüpfungen: | → Zeitschrift |
Comparison of gradient echo and gradient echo sampling of spin echo sequence for the quantification of the oxygen extraction fraction from a combined quantitative susceptibility mapping and quantitative BOLD (QSM+qBOLD) approach / Hubertus, Simon Ralph [VerfasserIn]; 02 June 2019 (Online-Ressource)