Computational approaches for identification of pleiotropic biomarker profiles in psychiatry

• Verfasst von: Cao, Han [VerfasserIn]
• Verfasst von: Schwarz, Emanuel [VerfasserIn]
• Titel: Computational approaches for identification of pleiotropic biomarker profiles in psychiatry
• Verf.angabe: Han Cao, Emanuel Schwarz
• E-Jahr: 2019
• Jahr: 28 March 2019
• Umfang: 18 S.
• Fussnoten: Gesehen am 19.11.2019
• Titel Quelle: Enthalten in: Reviews on biomarker studies of metabolic and metabolism-related disorders
• Ort Quelle: Cham : Springer, 2019
• Jahr Quelle: 2019
• Band/Heft Quelle: (2019), Seite 111-128
• ISBN Quelle: 978-3-030-12668-1
• DOI: doi:10.1007/978-3-030-12668-1_6
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Biomarkers
• Sach-SW: Computational approaches
• Sach-SW: Genetics
• Sach-SW: Metabolic disorders
• Sach-SW: Psychiatric disorders
• K10plus-PPN: 1682136809

Abstract

The discovery of biomarkers is considered a critical step towards an improved clinical management of psychiatric disorders. Despite the availability of advanced computational approaches, the lack of strong individual predictors of clinically relevant outcomes, combined with the usually high dimensionality, significantly hamper the identification of such markers. Consistent with the often observed lack of diagnostic specificity of biological alterations, research suggests an underlying genetic pleiotropy between psychiatric illnesses and frequently comorbid conditions, such as type 2 diabetes or cardiovascular illnesses. As research is transitioning away from conventional diagnostic delineations towards a dimensional understanding of psychiatric illness, gaining insight into such pleiotropy and its downstream biological effects bears promise for identification of clinically useful biomarkers. In this review, we summarize the computational methods for identifying biological markers indexing pleiotropic effects and discuss recent research findings in this context.