Calcium-Binding Proteins as Determinants of Central Nervous System Neuronal Vulnerability to Disease

• Verfasst von: Fairless, Richard [VerfasserIn]
• Verfasst von: Williams, Sarah K. [VerfasserIn]
• Verfasst von: Diem, Ricarda [VerfasserIn]
• Titel: Calcium-Binding Proteins as Determinants of Central Nervous System Neuronal Vulnerability to Disease
• Verf.angabe: Richard Fairless, Sarah K. Williams and Ricarda Diem
• E-Jahr: 2019
• Jahr: 30 April 2019
• Umfang: 14 S.
• Teil: volume:20
• Teil: year:2019
• Teil: number:9
• Teil: extent:14
• Fussnoten: Gesehen am 21.11.2019
• Titel Quelle: Enthalten in: International journal of molecular sciences
• Ort Quelle: Basel : Molecular Diversity Preservation International, 2000
• Jahr Quelle: 2019
• Band/Heft Quelle: 20(2019,9) Artikel-Nummer 2146, 14 Seiten
• ISSN Quelle: 1422-0067
• ISSN Quelle: 1661-6596
• DOI: doi:10.3390/ijms20092146
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1682419851

Abstract

Neuronal subpopulations display differential vulnerabilities to disease, but the factors that determine their susceptibility are poorly understood. Toxic increases in intracellular calcium are a key factor in several neurodegenerative processes, with calcium-binding proteins providing an important first line of defense through their ability to buffer incoming calcium, allowing the neuron to quickly achieve homeostasis. Since neurons expressing different calcium-binding proteins have been reported to be differentially susceptible to degeneration, it can be hypothesized that rather than just serving as markers of different neuronal subpopulations, they might actually be a key determinant of survival. In this review, we will summarize some of the evidence that expression of the EF-hand calcium-binding proteins, calbindin, calretinin and parvalbumin, may influence the susceptibility of distinct neuronal subpopulations to disease processes.