| |  Online-Ressource |
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| Verfasst von: | Görke, Steffen [VerfasserIn]  |
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| | Söhngen, Yannick [VerfasserIn] |
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| | Deshmane, Anagha [VerfasserIn] |
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| | Zaiss, Moritz [VerfasserIn] |
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| | Breitling, Johannes [VerfasserIn] |
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| | Boyd, Philip S. [VerfasserIn] |
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| | Herz, Kai [VerfasserIn] |
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| | Zimmermann, Ferdinand [VerfasserIn] |
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| | Klika, Karel D. [VerfasserIn] |
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| | Schlemmer, Heinz-Peter [VerfasserIn] |
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| | Paech, Daniel [VerfasserIn] |
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| | Ladd, Mark E. [VerfasserIn] |
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| | Bachert, Peter [VerfasserIn] |
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| Titel: | Relaxation-compensated APT and rNOE CEST-MRI of human brain tumors at 3 T |
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| Verf.angabe: | Steffen Goerke, Yannick Soehngen, Anagha Deshmane, Moritz Zaiss, Johannes Breitling, Philip S. Boyd, Kai Herz, Ferdinand Zimmermann, Karel D. Klika, Heinz-Peter Schlemmer, Daniel Paech, Mark E. Ladd, Peter Bachert |
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| E-Jahr: | 2019 |
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| Jahr: | 2 March 2019 |
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| Umfang: | 11 S. |
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| Fussnoten: | Gesehen am 22.11.2019 |
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| Titel Quelle: | Enthalten in: Magnetic resonance in medicine |
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| Ort Quelle: | New York, NY [u.a.] : Wiley-Liss, 1984 |
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| Jahr Quelle: | 2019 |
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| Band/Heft Quelle: | 82(2019), 2, Seite 622-632 |
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| ISSN Quelle: | 1522-2594 |
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| Abstract: | Purpose Relaxation-compensated CEST-MRI (i.e., the inverse metrics magnetization transfer ratio and apparent exchange-dependent relaxation) has already been shown to provide valuable information for brain tumor diagnosis at ultrahigh magnetic field strengths. This study aims at translating the established acquisition protocol at 7 T to a clinically relevant magnetic field strength of 3 T. Methods Protein model solutions were analyzed at multiple magnetic field strengths to assess the spectral widths of the amide proton transfer and relayed nuclear Overhauser effect (rNOE) signals at 3 T. This prior knowledge of the spectral range of CEST signals enabled a reliable and stable Lorentzian-fitting also at 3 T where distinct peaks are no longer resolved in the Z-spectrum. In comparison to the established acquisition protocol at 7 T, also the image readout was extended to three dimensions. Results The observed spectral range of CEST signals at 3 T was approximately ±15 ppm. Final relaxation-compensated amide proton transfer and relayed nuclear Overhauser effect contrasts were in line with previous results at 7 T. Examination of a patient with glioblastoma demonstrated the applicability of this acquisition protocol in a clinical setting. Conclusion The presented acquisition protocol allows relaxation-compensated CEST-MRI at 3 T with a 3D coverage of the human brain. Translation to a clinically relevant magnetic field strength of 3 T opens the door to trials with a large number of participants, thus enabling a comprehensive assessment of the clinical relevance of relaxation compensation in CEST-MRI. |
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| DOI: | doi:10.1002/mrm.27751 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag ; Resolving-System: https://doi.org/10.1002/mrm.27751 |
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| | Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/mrm.27751 |
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| | DOI: https://doi.org/10.1002/mrm.27751 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | APAT |
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| | cancer |
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| | CEST |
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| | MRI |
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| | proteins |
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| | rNOE |
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| K10plus-PPN: | 1682540332 |
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| Verknüpfungen: | → Zeitschrift |
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Relaxation-compensated APT and rNOE CEST-MRI of human brain tumors at 3 T / Görke, Steffen [VerfasserIn]; 2 March 2019 (Online-Ressource)
