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Status: Bibliographieeintrag

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Verfasst von:Görke, Steffen [VerfasserIn]   i
 Söhngen, Yannick [VerfasserIn]   i
 Deshmane, Anagha [VerfasserIn]   i
 Zaiss, Moritz [VerfasserIn]   i
 Breitling, Johannes [VerfasserIn]   i
 Boyd, Philip S. [VerfasserIn]   i
 Herz, Kai [VerfasserIn]   i
 Zimmermann, Ferdinand [VerfasserIn]   i
 Klika, Karel D. [VerfasserIn]   i
 Schlemmer, Heinz-Peter [VerfasserIn]   i
 Paech, Daniel [VerfasserIn]   i
 Ladd, Mark E. [VerfasserIn]   i
 Bachert, Peter [VerfasserIn]   i
Titel:Relaxation-compensated APT and rNOE CEST-MRI of human brain tumors at 3 T
Verf.angabe:Steffen Goerke, Yannick Soehngen, Anagha Deshmane, Moritz Zaiss, Johannes Breitling, Philip S. Boyd, Kai Herz, Ferdinand Zimmermann, Karel D. Klika, Heinz-Peter Schlemmer, Daniel Paech, Mark E. Ladd, Peter Bachert
E-Jahr:2019
Jahr:2 March 2019
Umfang:11 S.
Fussnoten:Gesehen am 22.11.2019
Titel Quelle:Enthalten in: Magnetic resonance in medicine
Ort Quelle:New York, NY [u.a.] : Wiley-Liss, 1984
Jahr Quelle:2019
Band/Heft Quelle:82(2019), 2, Seite 622-632
ISSN Quelle:1522-2594
Abstract:Purpose Relaxation-compensated CEST-MRI (i.e., the inverse metrics magnetization transfer ratio and apparent exchange-dependent relaxation) has already been shown to provide valuable information for brain tumor diagnosis at ultrahigh magnetic field strengths. This study aims at translating the established acquisition protocol at 7 T to a clinically relevant magnetic field strength of 3 T. Methods Protein model solutions were analyzed at multiple magnetic field strengths to assess the spectral widths of the amide proton transfer and relayed nuclear Overhauser effect (rNOE) signals at 3 T. This prior knowledge of the spectral range of CEST signals enabled a reliable and stable Lorentzian-fitting also at 3 T where distinct peaks are no longer resolved in the Z-spectrum. In comparison to the established acquisition protocol at 7 T, also the image readout was extended to three dimensions. Results The observed spectral range of CEST signals at 3 T was approximately ±15 ppm. Final relaxation-compensated amide proton transfer and relayed nuclear Overhauser effect contrasts were in line with previous results at 7 T. Examination of a patient with glioblastoma demonstrated the applicability of this acquisition protocol in a clinical setting. Conclusion The presented acquisition protocol allows relaxation-compensated CEST-MRI at 3 T with a 3D coverage of the human brain. Translation to a clinically relevant magnetic field strength of 3 T opens the door to trials with a large number of participants, thus enabling a comprehensive assessment of the clinical relevance of relaxation compensation in CEST-MRI.
DOI:doi:10.1002/mrm.27751
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag ; Resolving-System: https://doi.org/10.1002/mrm.27751
 Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/mrm.27751
 DOI: https://doi.org/10.1002/mrm.27751
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:APAT
 cancer
 CEST
 MRI
 proteins
 rNOE
K10plus-PPN:1682540332
Verknüpfungen:→ Zeitschrift

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