| Online-Ressource |
Verfasst von: | Görke, Steffen [VerfasserIn]  |
| Söhngen, Yannick [VerfasserIn]  |
| Deshmane, Anagha [VerfasserIn]  |
| Zaiss, Moritz [VerfasserIn]  |
| Breitling, Johannes [VerfasserIn]  |
| Boyd, Philip S. [VerfasserIn]  |
| Herz, Kai [VerfasserIn]  |
| Zimmermann, Ferdinand [VerfasserIn]  |
| Klika, Karel D. [VerfasserIn]  |
| Schlemmer, Heinz-Peter [VerfasserIn]  |
| Paech, Daniel [VerfasserIn]  |
| Ladd, Mark E. [VerfasserIn]  |
| Bachert, Peter [VerfasserIn]  |
Titel: | Relaxation-compensated APT and rNOE CEST-MRI of human brain tumors at 3 T |
Verf.angabe: | Steffen Goerke, Yannick Soehngen, Anagha Deshmane, Moritz Zaiss, Johannes Breitling, Philip S. Boyd, Kai Herz, Ferdinand Zimmermann, Karel D. Klika, Heinz-Peter Schlemmer, Daniel Paech, Mark E. Ladd, Peter Bachert |
E-Jahr: | 2019 |
Jahr: | 2 March 2019 |
Umfang: | 11 S. |
Fussnoten: | Gesehen am 22.11.2019 |
Titel Quelle: | Enthalten in: Magnetic resonance in medicine |
Ort Quelle: | New York, NY [u.a.] : Wiley-Liss, 1984 |
Jahr Quelle: | 2019 |
Band/Heft Quelle: | 82(2019), 2, Seite 622-632 |
ISSN Quelle: | 1522-2594 |
Abstract: | Purpose Relaxation-compensated CEST-MRI (i.e., the inverse metrics magnetization transfer ratio and apparent exchange-dependent relaxation) has already been shown to provide valuable information for brain tumor diagnosis at ultrahigh magnetic field strengths. This study aims at translating the established acquisition protocol at 7 T to a clinically relevant magnetic field strength of 3 T. Methods Protein model solutions were analyzed at multiple magnetic field strengths to assess the spectral widths of the amide proton transfer and relayed nuclear Overhauser effect (rNOE) signals at 3 T. This prior knowledge of the spectral range of CEST signals enabled a reliable and stable Lorentzian-fitting also at 3 T where distinct peaks are no longer resolved in the Z-spectrum. In comparison to the established acquisition protocol at 7 T, also the image readout was extended to three dimensions. Results The observed spectral range of CEST signals at 3 T was approximately ±15 ppm. Final relaxation-compensated amide proton transfer and relayed nuclear Overhauser effect contrasts were in line with previous results at 7 T. Examination of a patient with glioblastoma demonstrated the applicability of this acquisition protocol in a clinical setting. Conclusion The presented acquisition protocol allows relaxation-compensated CEST-MRI at 3 T with a 3D coverage of the human brain. Translation to a clinically relevant magnetic field strength of 3 T opens the door to trials with a large number of participants, thus enabling a comprehensive assessment of the clinical relevance of relaxation compensation in CEST-MRI. |
DOI: | doi:10.1002/mrm.27751 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag ; Resolving-System: https://doi.org/10.1002/mrm.27751 |
| Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/mrm.27751 |
| DOI: https://doi.org/10.1002/mrm.27751 |
Datenträger: | Online-Ressource |
Sprache: | eng |
Sach-SW: | APAT |
| cancer |
| CEST |
| MRI |
| proteins |
| rNOE |
K10plus-PPN: | 1682540332 |
Verknüpfungen: | → Zeitschrift |
Relaxation-compensated APT and rNOE CEST-MRI of human brain tumors at 3 T / Görke, Steffen [VerfasserIn]; 2 March 2019 (Online-Ressource)