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| Verfasst von: | Wischnjow, Artjom [VerfasserIn]  |
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| | Sarko, Dikran [VerfasserIn] |
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| | Janzer, Maria [VerfasserIn] |
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| | Kaufman, Christina [VerfasserIn] |
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| | Beijer, Barbro [VerfasserIn] |
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| | Brings, Sebastian [VerfasserIn] |
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| | Haberkorn, Uwe [VerfasserIn] |
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| | Mier, Walter [VerfasserIn] |
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| Titel: | Renal targeting |
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| Titelzusatz: | peptide-based drug delivery to proximal tubule cells |
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| Verf.angabe: | Artjom Wischnjow, Dikran Sarko, Maria Janzer, Christina Kaufman, Barbro Beijer, Sebastian Brings, Uwe Haberkorn, Gregor Larbig, Armin Kübelbeck, and Walter Mier |
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| E-Jahr: | 2016 |
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| Jahr: | March 21, 2016 |
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| Umfang: | 8 S. |
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| Fussnoten: | Gesehen am 25.11.2019 |
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| Titel Quelle: | Enthalten in: Bioconjugate chemistry |
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| Ort Quelle: | Columbus, Ohio : American Chemical Society, 1990 |
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| Jahr Quelle: | 2016 |
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| Band/Heft Quelle: | 27(2016), 4, Seite 1050-1057 |
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| ISSN Quelle: | 1520-4812 |
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| Abstract: | Kidney-specific drug targeting is an attractive strategy to reduce unwanted side effects and to enhance drug efficacy within the renal tissue. For this purpose a novel kidney-specific drug carrier was developed. The peptide sequence (KKEEE)3K triggers exceptional renal specificity at high accumulation rates. Micro-PET imaging studies of megalin-deficient mice indicate that the cellular endocytosis of this carrier is mediated by megalin. This assumption is supported by immunohistochemical analysis of FITC-labeled carrier peptide, which exclusively accumulated at the apical side of proximal tubule cells within the renal cortex. Scintigraphic studies of modified ciprofloxacin conjugated to (KKEEE)3K confirmed the excellent drug targeting potential of the peptide carrier. The conjugate accumulated entirely in the kidneys, revealing flawless redirection of ciprofloxacin, a compound that is mainly excreted by the liver. In conclusion, these results suggest the potential of (KKEEE)3K as a promising candidate for kidney-targeted drug delivery to proximal tubule cells. |
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| DOI: | doi:10.1021/acs.bioconjchem.6b00057 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1021/acs.bioconjchem.6b00057 |
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| | DOI: https://doi.org/10.1021/acs.bioconjchem.6b00057 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1683393570 |
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| Verknüpfungen: | → Zeitschrift |
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Renal targeting / Wischnjow, Artjom [VerfasserIn]; March 21, 2016 (Online-Ressource)
