German Cardiac Society Working Group on Cellular Electrophysiology state-of-the-art paper

• Verfasst von: Thomas, Dierk [VerfasserIn]
• Verfasst von: Christ, Torsten [VerfasserIn]
• Verfasst von: Fabritz, Larissa [VerfasserIn]
• Verfasst von: Goette, Andreas [VerfasserIn]
• Verfasst von: Hammwöhner, Matthias [VerfasserIn]
• Verfasst von: Heijman, Jordi [VerfasserIn]
• Verfasst von: Kockskämper, Jens [VerfasserIn]
• Verfasst von: Linz, Dominik [VerfasserIn]
• Verfasst von: Odening, Katja Elisabeth [VerfasserIn]
• Verfasst von: Schweizer, Patrick Alexander [VerfasserIn]
• Verfasst von: Wakili, Reza [VerfasserIn]
• Verfasst von: Voigt, Niels [VerfasserIn]
• Titel: German Cardiac Society Working Group on Cellular Electrophysiology state-of-the-art paper
• Titelzusatz: impact of molecular mechanisms on clinical arrhythmia management
• Verf.angabe: Dierk Thomas, Torsten Christ, Larissa Fabritz, Andreas Goette, Matthias Hammwöhner, Jordi Heijman, Jens Kockskämper, Dominik Linz, Katja E. Odening, Patrick A. Schweizer, Reza Wakili, Niels Voigt
• Jahr: 2019
• Umfang: 23 S.
• Fussnoten: Published online: 10 October 2018 ; Gesehen am 26.11.2019
• Titel Quelle: Enthalten in: Clinical research in cardiology
• Ort Quelle: Berlin : Springer, 2006
• Jahr Quelle: 2019
• Band/Heft Quelle: 108(2019), 6, Seite 577-599
• ISSN Quelle: 1861-0692
• DOI: doi:10.1007/s00392-018-1377-1
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Antiarrhythmic therapy
• Sach-SW: Arrhythmogenesis
• Sach-SW: Cellular electrophysiology
• Sach-SW: Ion channels
• Sach-SW: Pathophysiology
• K10plus-PPN: 1683476670

Abstract

Cardiac arrhythmias remain a common challenge and are associated with significant morbidity and mortality. Effective and safe rhythm control strategies are a primary, yet unmet need in everyday clinical practice. Despite significant pharmacological and technological advances, including catheter ablation and device-based therapies, the development of more effective alternatives is of significant interest to increase quality of life and to reduce symptom burden, hospitalizations and mortality. The mechanistic understanding of pathophysiological pathways underlying cardiac arrhythmias has advanced profoundly, opening up novel avenues for mechanism-based therapeutic approaches. Current management of arrhythmias, however, is primarily guided by clinical and demographic characteristics of patient groups as opposed to individual, patient-specific mechanisms and pheno-/genotyping. With this state-of-the-art paper, the Working Group on Cellular Electrophysiology of the German Cardiac Society aims to close the gap between advanced molecular understanding and clinical decision-making in cardiac electrophysiology. The significance of cellular electrophysiological findings for clinical arrhythmia management constitutes the main focus of this document. Clinically relevant knowledge of pathophysiological pathways of arrhythmias and cellular mechanisms of antiarrhythmic interventions are summarized. Furthermore, the specific molecular background for the initiation and perpetuation of atrial and ventricular arrhythmias and mechanism-based strategies for therapeutic interventions are highlighted. Current “hot topics” in atrial fibrillation are critically appraised. Finally, the establishment and support of cellular and translational electrophysiology programs in clinical rhythmology departments is called for to improve basic-science-guided patient management.