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| Verfasst von: | Kober, Katharina Isabelle [VerfasserIn]  |
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| | Géraud, Cyrill [VerfasserIn] |
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| | Boutros, Michael [VerfasserIn] |
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| Titel: | Loxl2 is dispensable for dermal development, homeostasis and tumour stroma formation |
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| Verf.angabe: | Katharina Isabelle Kober, Amparo Cano, Cyrill Géraud, Kalle Sipilä, Seyedeh Atefeh Mobasseri, Christina Philippeos, Angela Oliveira Pisco, Andrew Stannard, Alberto Martin, Fernando Salvador, Vanesa Santos, Michael Boutros, Emanuel Rognoni, Fiona M. Watt |
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| E-Jahr: | 2018 |
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| Jahr: | June 28, 2018 |
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| Fussnoten: | Gesehen am 27.11.2019 |
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| Titel Quelle: | Enthalten in: PLOS ONE |
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| Ort Quelle: | San Francisco, California, US : PLOS, 2006 |
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| Jahr Quelle: | 2018 |
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| Band/Heft Quelle: | 13(2018,6) Artikel-Nummer e0199679, 18 Seiten |
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| ISSN Quelle: | 1932-6203 |
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| Abstract: | Lysyl oxidase-like 2 (LOXL2) is a copper-dependent monoamine oxidase that contributes to the remodelling of the extracellular matrix (ECM) by cross linkage of collagen and elastin fibres and has emerged as a potential therapeutic target in cancer and fibrosis. In the skin, LOXL2 is essential for epidermal cell polarity and differentiation. However, its role in the dermis has not been evaluated. We found that Loxl2 is dispensable for mouse dermal development, maturation and homeostasis, yet affects dermal stiffness. Neither loss of Loxl2 nor increased Loxl2 expression affected dermal architecture following treatment with the phorbol ester TPA. Furthermore, Loxl2 expression did not alter the stroma of DMBA-TPA-induced tumours. We conclude that, although Loxl2 is expressed in both dermis and epidermis, its function appears largely confined to the epidermis. |
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| DOI: | doi:10.1371/journal.pone.0199679 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1371/journal.pone.0199679 |
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| | Verlag: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0199679 |
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| | DOI: https://doi.org/10.1371/journal.pone.0199679 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Collagens |
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| | DAPI staining |
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| | Dermis |
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| | Fibroblasts |
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| | Hematoxylin staining |
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| | Homeostasis |
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| | Mouse models |
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| | Skin tumors |
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| K10plus-PPN: | 1683622693 |
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| Verknüpfungen: | → Zeitschrift |
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Loxl2 is dispensable for dermal development, homeostasis and tumour stroma formation / Kober, Katharina Isabelle [VerfasserIn]; June 28, 2018 (Online-Ressource)
