Caspofungin modulates ryanodine receptor-mediated calcium release in human cardiac myocytes

• Verfasst von: Koch, Christian [VerfasserIn]
• Verfasst von: Uhle, Florian [VerfasserIn]
• Verfasst von: Weigand, Markus A. [VerfasserIn]
• Titel: Caspofungin modulates ryanodine receptor-mediated calcium release in human cardiac myocytes
• Verf.angabe: Christian Koch, Jennifer Jersch, Emmanuel Schneck, Fabian Edinger, Hagen Maxeiner, Florian Uhle, Markus A. Weigand, Melanie Markmann, Michael Sander, Michael Henrich
• E-Jahr: 2018
• Jahr: October 24, 2018
• Fussnoten: Accepted manuscript posted online 27 August 2018 ; Gesehen am 27.11.2019
• Titel Quelle: Enthalten in: Antimicrobial agents and chemotherapy
• Ort Quelle: Washington, DC : Soc., 1972
• Jahr Quelle: 2018
• Band/Heft Quelle: 62(2018,11) Artikel-Nummer e01114-18, 5 Seiten
• ISSN Quelle: 1098-6596
• DOI: doi:10.1128/AAC.01114-18
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1683627911

Abstract

Recent studies showed that critically ill patients might be at risk for hemodynamic impairment during caspofungin (CAS) therapy. The aim of our present study was to examine the mechanisms behind CAS-induced cardiac alterations. We revealed a dose-dependent increase in intracellular Ca2+ concentration ([Ca2+]i) after CAS treatment. Ca2+ ions were found to be released from intracellular caffeine-sensitive stores, most probably via the activation of ryanodine receptors.