The association of high-sensitivity cardiac troponin I and T with echocardiographic stages of heart failure with preserved ejection fraction

• Verfasst von: Hoffmann, Julia [VerfasserIn]
• Verfasst von: Behnes, Michael [VerfasserIn]
• Verfasst von: Ansari, Uzair [VerfasserIn]
• Verfasst von: Weidner, Kathrin [VerfasserIn]
• Verfasst von: Kuche, Philipp [VerfasserIn]
• Verfasst von: Rusnak, Jonas [VerfasserIn]
• Verfasst von: Kim, Seung‑Hyun [VerfasserIn]
• Verfasst von: Natale, Michèle [VerfasserIn]
• Verfasst von: Reckord, Nadine [VerfasserIn]
• Verfasst von: Lang, Siegfried [VerfasserIn]
• Verfasst von: Hoffmann, Ursula [VerfasserIn]
• Verfasst von: Bertsch, Thomas [VerfasserIn]
• Verfasst von: Fatar, Marc [VerfasserIn]
• Verfasst von: Borggrefe, Martin [VerfasserIn]
• Verfasst von: Akın, Ibrahim [VerfasserIn]
• Titel: The association of high-sensitivity cardiac troponin I and T with echocardiographic stages of heart failure with preserved ejection fraction
• Verf.angabe: Julia Hoffmann, Michael Behnes, Uzair Ansari, Kathrin Weidner, Philip Kuche, Jonas Rusnak, Seung-Hyun Kim, Michele Natale, Nadine Reckord, Siegfried Lang, Ursula Hoffmann, Thomas Bertsch, Marc Fatar, Martin Borggrefe, Ibrahim Akin
• E-Jahr: 2019
• Jahr: May 21, 2019
• Umfang: 11 S.
• Fussnoten: Gesehen am 28.11.2019
• Titel Quelle: Enthalten in: Annals of clinical biochemistry
• Ort Quelle: London : Sage, 1960
• Jahr Quelle: 2019
• Band/Heft Quelle: 56(2019), 4, Seite 431-441
• ISSN Quelle: 1758-1001
• DOI: doi:10.1177/0004563219841644
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1683728181

Abstract

Background: This study evaluates the associations between high-sensitivity troponin I and T (hs-TnI/hs-TnT) and the stages of heart failure with preserved ejection fraction (HFpEF)/diastolic dysfunction. Methods: Blood samples for biomarker measurements (hs-TnI/hs-TnT/NT-proBNP) were collected within 24 h of routine echocardiographic examination. Patients with left ventricular ejection fraction <50%, right ventricular dysfunction and moderate-to-severe valvular heart disease were excluded. Graduation of diastolic dysfunction was determined according to current guidelines. Results: A total of 70 patients were included. Hs-TnT concentrations increased significantly according to the progression of diastolic dysfunction (P = 0.024). Hs-TnT was able to discriminate patients with diastolic dysfunction grade III (AUC = 0.737; P = 0.013), while NT-proBNP revealed a greater AUC (AUC 0.798; P = 0.002). Concentrations of hs-TnI increased only numerically according to the increasing stages of diastolic dysfunction (P = 0.353). In multivariable logistic regression models, hs-TnT concentrations > 28 ng/L were associated with diastolic dysfunction grade III (OR = 4.7, P = 0.024), even after adjusting for NT-proBNP. Conclusion: Increasing concentrations of hs-TnT may reflect the stages of diastolic dysfunction being assessed by echocardiography, whereas hs-TnI does not show any association with diastolic dysfunction.