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Verfasst von:Zidda, Francesca [VerfasserIn]   i
 Griebe, Martin [VerfasserIn]   i
 Ebert, Anne [VerfasserIn]   i
 Ruttorf, Michaela [VerfasserIn]   i
 Roßmanith, Christina [VerfasserIn]   i
 Gass, Achim [VerfasserIn]   i
 Nees, Frauke [VerfasserIn]   i
 Szabo, Kristina [VerfasserIn]   i
Titel:Resting-state connectivity alterations during transient global amnesia
Verf.angabe:Francesca Zidda, Martin Griebe, Anne Ebert, Michaela Ruttorf, Christina Roßmanith, Achim Gass, Jamila Andoh, Frauke Nees, Kristina Szabo
E-Jahr:2019
Jahr:23 May 2019
Umfang:8 S.
Fussnoten:Gesehen am 29.11.2019
Titel Quelle:Enthalten in: NeuroImage: Clinical
Ort Quelle:[Amsterdam u.a.] : Elsevier, 2012
Jahr Quelle:2019
Band/Heft Quelle:23(2019) Artikel-Nummer 101869, 8 Seiten
ISSN Quelle:2213-1582
Abstract:While the pathophysiology of transient global amnesia (TGA) is not understood, due to the specific nature of the clinical deficits, transient dysfunction in the medial temporal lobe, especially in the hippocampus, is assumed; however, concomitant disturbances in other brain regions and in executive function have been postulated. In this study, a cohort of 16 patients was prospectively recruited from the emergency department for resting-state functional MRI (fMRI) during the acute stage of TGA, as confirmed by a standardized neuropsychological assessment. Twenty age- and sex-matched controls, as well as twenty patients with a history of TGA, were recruited for comparison. Functional data were processed using independent component analysis (ICA), allowing the complete automatic (data-driven) identification of spontaneous network dynamics. We documented a severe disturbance in anterograde episodic long-term memory in all patients. Group-based ICA of resting-state data in acute TGA patients versus that of controls and patients with a past TGA episode demonstrated reduced FC mainly of structures belonging to the executive network (EN), but also the hippocampus, confirming its pathophysiological involvement in the disorder, as well as areas belonging to the salience network and other subcortical regions. No significant differences were found when comparing connectivity in patients with a history of TGA and controls. Our findings strengthen previous empirical and theoretical accounts of hippocampal and executive dysfunction in TGA. The disruption of frontal, parietal and insular control regions, together with disruption in the hippocampus, provides a new interpretation for the pathophysiology and neuropsychological profile of this neurological disorder on a large-scale network level
DOI:doi:10.1016/j.nicl.2019.101869
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

kostenfrei: Volltext: https://doi.org/10.1016/j.nicl.2019.101869
 kostenfrei: Volltext: http://www.sciencedirect.com/science/article/pii/S2213158219302190
 DOI: https://doi.org/10.1016/j.nicl.2019.101869
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Executive network
 Hippocampus
 Memory
 Resting-state functional connectivity
 Transient global amnesia
K10plus-PPN:1683848608
Verknüpfungen:→ Zeitschrift

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