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Status: Bibliographieeintrag

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Verfasst von:Chaudhary, Varun [VerfasserIn]   i
 Boutros, Michael [VerfasserIn]   i
Titel:Robust Wnt signaling is maintained by a Wg protein gradient and Fz2 receptor activity in the developing Drosophila wing
Verf.angabe:Varun Chaudhary, Swapnil Hingole, Jana Frei, Fillip Port, David Strutt and Michael Boutros
E-Jahr:2019
Jahr:9 August 2019
Umfang:12 S.
Fussnoten:Gesehen am 02.12.2019
Titel Quelle:Enthalten in: Development
Ort Quelle:Cambridge : The Company of Biologists, 1953
Jahr Quelle:2019
Band/Heft Quelle:146(2019,15) Artikel-Nummer dev174789, 12 Seiten
ISSN Quelle:1477-9129
Abstract:Skip to Next Section - Wnts are secreted proteins that regulate cell fate during development of all metazoans. Wnt proteins were proposed to spread over several cells to activate signaling directly at a distance. In the Drosophila wing epithelium, an extracellular gradient of the Wnt1 homolog Wingless (Wg) was observed extending over several cells away from producing cells. Surprisingly, however, it was also shown that a membrane-tethered Neurotactin-Wg fusion protein (NRT-Wg) can largely replace endogenous Wg, leading to proper patterning of the wing. Therefore, the functional range of Wg and whether Wg spreading is required for correct tissue patterning remains controversial. Here, by capturing secreted Wg on cells away from the source, we show that Wg acts over a distance of up to 11 cell diameters to induce signaling. Furthermore, cells located outside the reach of extracellular Wg depend on the Frizzled2 receptor to maintain signaling. Frizzled2 expression is increased in the absence of Wg secretion and is required to maintain signaling and cell survival in NRT-wg wing discs. Together, these results provide insight into the mechanisms by which robust Wnt signaling is achieved in proliferating tissues.
DOI:doi:10.1242/dev.174789
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1242/dev.174789
 Volltext: https://dev.biologists.org/content/146/15/dev174789
 DOI: https://doi.org/10.1242/dev.174789
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1683885430
Verknüpfungen:→ Zeitschrift

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