Status: Bibliographieeintrag
Standort: ---
Exemplare:
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| Online-Ressource |
Verfasst von: | Dasanna, Anil Kumar [VerfasserIn]  |
| Fedosov, Dmitry A. [VerfasserIn]  |
| Gompper, Gerhard [VerfasserIn]  |
| Schwarz, Ulrich S. [VerfasserIn]  |
Titel: | State diagram for wall adhesion of red blood cells in shear flow |
Titelzusatz: | from crawling to flipping |
Verf.angabe: | Anil K. Dasanna, Dmitry A. Fedosov, Gerhard Gompper and Ulrich S. Schwarz |
E-Jahr: | 2019 |
Jahr: | 19 Jun 2019 |
Umfang: | 10 S. |
Fussnoten: | Gesehen am 04.12.2019 |
Titel Quelle: | Enthalten in: Soft matter |
Ort Quelle: | London : Royal Soc. of Chemistry, 2005 |
Jahr Quelle: | 2019 |
Band/Heft Quelle: | 15(2019), 27, Seite 5511-5520 |
ISSN Quelle: | 1744-6848 |
Abstract: | Red blood cells in shear flow show a variety of different shapes due to the complex interplay between hydrodynamics and membrane elasticity. Malaria-infected red blood cells become generally adhesive and less deformable. Adhesion to a substrate leads to a reduction in shape variability and to a flipping motion of the non-spherical shapes during the mid-stage of infection. Here, we present a complete state diagram for wall adhesion of red blood cells in shear flow obtained by simulations, using a particle-based mesoscale hydrodynamics approach, multiparticle collision dynamics. We find that cell flipping at a substrate is replaced by crawling beyond a critical shear rate, which increases with both membrane stiffness and viscosity contrast between the cytosol and suspending medium. This change in cell dynamics resembles the transition between tumbling and tank-treading for red blood cells in free shear flow. In the context of malaria infections, the flipping-crawling transition would strongly increase the adhesive interactions with the vascular endothelium, but might be suppressed by the combined effect of increased elasticity and viscosity contrast. |
DOI: | doi:10.1039/C9SM00677J |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1039/C9SM00677J |
| Verlag: https://pubs.rsc.org/en/content/articlelanding/2019/sm/c9sm00677j |
| DOI: https://doi.org/10.1039/C9SM00677J |
Datenträger: | Online-Ressource |
Sprache: | eng |
K10plus-PPN: | 168414342X |
Verknüpfungen: | → Zeitschrift |
State diagram for wall adhesion of red blood cells in shear flow / Dasanna, Anil Kumar [VerfasserIn]; 19 Jun 2019 (Online-Ressource)
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