State diagram for wall adhesion of red blood cells in shear flow

• Verfasst von: Dasanna, Anil Kumar [VerfasserIn]
• Verfasst von: Fedosov, Dmitry A. [VerfasserIn]
• Verfasst von: Gompper, Gerhard [VerfasserIn]
• Verfasst von: Schwarz, Ulrich S. [VerfasserIn]
• Titel: State diagram for wall adhesion of red blood cells in shear flow
• Titelzusatz: from crawling to flipping
• Verf.angabe: Anil K. Dasanna, Dmitry A. Fedosov, Gerhard Gompper and Ulrich S. Schwarz
• E-Jahr: 2019
• Jahr: 19 Jun 2019
• Umfang: 10 S.
• Fussnoten: Gesehen am 04.12.2019
• Titel Quelle: Enthalten in: Soft matter
• Ort Quelle: London : Royal Soc. of Chemistry, 2005
• Jahr Quelle: 2019
• Band/Heft Quelle: 15(2019), 27, Seite 5511-5520
• ISSN Quelle: 1744-6848
• DOI: doi:10.1039/C9SM00677J
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 168414342X

Abstract

Red blood cells in shear flow show a variety of different shapes due to the complex interplay between hydrodynamics and membrane elasticity. Malaria-infected red blood cells become generally adhesive and less deformable. Adhesion to a substrate leads to a reduction in shape variability and to a flipping motion of the non-spherical shapes during the mid-stage of infection. Here, we present a complete state diagram for wall adhesion of red blood cells in shear flow obtained by simulations, using a particle-based mesoscale hydrodynamics approach, multiparticle collision dynamics. We find that cell flipping at a substrate is replaced by crawling beyond a critical shear rate, which increases with both membrane stiffness and viscosity contrast between the cytosol and suspending medium. This change in cell dynamics resembles the transition between tumbling and tank-treading for red blood cells in free shear flow. In the context of malaria infections, the flipping-crawling transition would strongly increase the adhesive interactions with the vascular endothelium, but might be suppressed by the combined effect of increased elasticity and viscosity contrast.