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Verfasst von:Soeda, Fumihiko [VerfasserIn]   i
 Watabe, Tadashi [VerfasserIn]   i
 Naka, Sadahiro [VerfasserIn]   i
 Liu, Yuwei [VerfasserIn]   i
 Horitsugi, Genki [VerfasserIn]   i
 Neels, Oliver C. [VerfasserIn]   i
 Kopka, Klaus [VerfasserIn]   i
 Tatsumi, Mitsuaki [VerfasserIn]   i
 Shimosegawa, Eku [VerfasserIn]   i
 Giesel, Frederik L. [VerfasserIn]   i
 Hatazawa, Jun [VerfasserIn]   i
Titel:Impact of 18F-PSMA-1007 uptake in prostate cancer using different peptide concentrations
Titelzusatz:preclinical PET/CT study on mice
Verf.angabe:Fumihiko Soeda, Tadashi Watabe, Sadahiro Naka, Yuwei Liu, Genki Horitsugi, Oliver C. Neels, Klaus Kopka, Mitsuaki Tatsumi, Eku Shimosegawa, Frederik L. Giesel, and Jun Hatazawa
E-Jahr:2019
Jahr:Mar. 22, 2019
Umfang:6 S.
Fussnoten:Gesehen am 04.12.2019
Titel Quelle:Enthalten in: Journal of nuclear medicine
Ort Quelle:New York, NY : Soc., 1964
Jahr Quelle:2019
Band/Heft Quelle:60(2019), 11, Seite 1594-1599
ISSN Quelle:2159-662X
 1535-5667
Abstract:PET radioligands with low molar activity (MA) may underestimate the quantity of the target of interest because of competitive binding of the target with unlabeled ligand. The aim of this study was to evaluate the change in the whole-body distribution of 18F-PSMA-1007 targeting prostate-specific membrane antigen (PSMA) when solutions with different peptide concentrations are used. Methods: Mouse xenograft models of LNCaP (PSMA-positive prostate cancer) (n = 18) were prepared and divided into 3 groups according to the peptide concentration injected: a high-MA group (1,013 ± 146 GBq/μmol; n = 6), a medium-MA group (100.7 ± 23.1 GBq/μmol; n = 6), and a low-MA group (10.80 ± 2.84 GBq/μmol; n = 6). Static PET scans were performed 1 h after injection (scan duration, 10 min). SUVmean in tumor and normal organs was compared by the multiple-comparison test. Immunohistochemical staining and Western blot analysis were performed to confirm expression of PSMA in tumor, salivary gland, and kidney. Results: The low-MA group (SUVmean, 1.12 ± 0.30) showed significantly lower uptake of 18F-PSMA-1007 in tumor than did the high-MA group (1.97 ± 0.77) and the medium-MA group (1.81 ± 0.57). On the other hand, in salivary gland, both the low-MA group (SUVmean, 0.24 ± 0.04) and the medium-MA group (0.57 ± 0.08) showed significantly lower uptake than the high MA group (1.27 ± 0.28). The tumor-to-salivary gland SUVmean ratio was 1.73 ± 0.55 in the high-MA group, 3.16 ± 0.86 in the medium-MA group, and 4.78 ± 1.29 in the low-MA group. The immunohistochemical staining and Western blot analysis revealed significant overexpression of PSMA in tumor and low expression in salivary gland and kidney. Conclusion: A decrease in the MA level of the injected 18F-PSMA-1007 solution resulted in decreased uptake in tumor and, to a greater degree, in normal salivary gland. Thus, there is a possibility of minimizing the adverse effects in salivary gland by setting an appropriate MA level in PSMA-targeting therapy.
DOI:doi:10.2967/jnumed.118.223479
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: https://doi.org/10.2967/jnumed.118.223479
 Volltext: http://jnm.snmjournals.org/content/60/11/1594
 DOI: https://doi.org/10.2967/jnumed.118.223479
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:18F-PSMA-1007
 molar activity
 peptide concentration
 prostate cancer
 salivary gland
K10plus-PPN:1684200091
Verknüpfungen:→ Zeitschrift

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