| |  Online-Ressource |
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| Verfasst von: | Himbert, Caroline [VerfasserIn]  |
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| | Ose, Jennifer [VerfasserIn] |
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| | Lin, Tengda [VerfasserIn] |
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| | Warby, Christy A. [VerfasserIn] |
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| | Gigić, Biljana [VerfasserIn] |
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| | Steindorf, Karen [VerfasserIn] |
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| | Schrotz-King, Petra [VerfasserIn] |
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| | Abbenhardt-Martin, Clare [VerfasserIn] |
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| | Zielske, Lin [VerfasserIn] |
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| | Böhm, Jürgen [VerfasserIn] |
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| | Ulrich, Cornelia [VerfasserIn] |
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| Titel: | Inflammation- and angiogenesis-related biomarkers are correlated with cancer-related fatigue in colorectal cancer patients |
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| Titelzusatz: | results from the ColoCare Study |
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| Verf.angabe: | Caroline Himbert, Jennifer Ose, Tengda Lin, Christy A. Warby, Biljana Gigic, Karen Steindorf, Petra Schrotz‐King, Clare Abbenhardt‐Martin, Lin Zielske, Juergen Boehm, Cornelia M. Ulrich |
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| E-Jahr: | 2019 |
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| Jahr: | 24 April 2019 |
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| Umfang: | 10 S. |
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| Fussnoten: | Gesehen am 05.12.2019 |
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| Titel Quelle: | Enthalten in: European journal of cancer care |
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| Ort Quelle: | Oxford [u.a.] : Wiley-Blackwell, 1992 |
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| Jahr Quelle: | 2019 |
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| Band/Heft Quelle: | 28(2019,4) Artikel-Nummer e13055, 10 Seiten |
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| ISSN Quelle: | 1365-2354 |
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| Abstract: | Cancer-related fatigue is one of the most common side effects of colorectal cancer treatment and is affected by biomedical factors. We investigated the association of inflammation- and angiogenesis-related biomarkers with cancer-related fatigue. Pre-surgery (baseline) serum samples were obtained from n = 236 newly diagnosed colorectal cancer patients. Meso Scale Discovery assays were performed to measure levels of biomarkers for inflammation and angiogenesis (CRP, SAA, IL-6, IL-8, MCP-1, sICAM-1, sVCAM-1, TNFα, VEGFA and VEGFD). Cancer-related fatigue was assessed with the EORTC QLQ-30 questionnaire at baseline and 6 and 12 months post-surgery. We tested associations using Spearman's partial correlations and logistic regression analyses, adjusting for age, sex and body mass index. sICAM-1 and VEGFD showed a significant positive correlation with cancer-related fatigue at baseline and 6-, and 12-month follow-up (sICAM-1: r = 0.19, p = 0.010; r = 0.24, p = 0.004; r = 0.25, p = 0.006; VEGFD: r = 0.20, p = 0.006; r = 0.15, p = 0.06; r = 0.23, p = 0.01 respectively). Biomarkers of inflammation and angiogenesis measured prior to surgery are associated with cancer-related fatigue in colorectal cancer patients throughout various time points. Our results suggest the involvement of overexpressed sICAM-1 and VEGFD in the development of fatigue. |
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| DOI: | doi:10.1111/ecc.13055 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1111/ecc.13055 |
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| | Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/ecc.13055 |
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| | DOI: https://doi.org/10.1111/ecc.13055 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | angiogenesis |
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| | biomarker |
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| | colorectal cancer |
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| | fatigue |
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| | inflammation |
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| K10plus-PPN: | 1684388082 |
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| Verknüpfungen: | → Zeitschrift |
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Inflammation- and angiogenesis-related biomarkers are correlated with cancer-related fatigue in colorectal cancer patients / Himbert, Caroline [VerfasserIn]; 24 April 2019 (Online-Ressource)
