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Status: Bibliographieeintrag

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Verfasst von:Held, Thomas [VerfasserIn]   i
 Verbeke, Caroline S. [VerfasserIn]   i
 Strobel, Oliver [VerfasserIn]   i
 Rutkowski, Wiktor [VerfasserIn]   i
 Villard, Christina [VerfasserIn]   i
 Moro, Carlos Fernández [VerfasserIn]   i
 Del Chiaro, Marco [VerfasserIn]   i
 Büchler, Markus W. [VerfasserIn]   i
 Heuchel, Rainer [VerfasserIn]   i
 Löhr, J.-Matthias [VerfasserIn]   i
Titel:Immunohistochemical profiling of liver metastases and matched-pair analysis in patients with metastatic pancreatic ductal adenocarcinoma
Verf.angabe:Thomas Held, Caroline S. Verbeke, Oliver Strobel, Wiktor Rutkowski, Christina Villard, Carlos Fernández Moro, Marco Del Chiaro, Markus Büchler, Rainer Heuchel, Matthias Löhr
E-Jahr:2019
Jahr:14 September 2019
Umfang:8 S.
Fussnoten:Gesehen am 05.12.2019
Titel Quelle:Enthalten in: Pancreatology
Ort Quelle:Amsterdam : Elsevier, 2001
Jahr Quelle:2019
Band/Heft Quelle:19(2019), 7, Seite 963-970
ISSN Quelle:1424-3911
Abstract:Background - The purpose of the current study was to investigate the immunohistochemical (IHC) profile of liver metastases (LM) in patients with pancreatic ductal adenocarcinoma (PDAC). - Methods - Expression of 15 IHC markers in liver biopsies from 77 patients with PDAC, who were diagnosed between 2010 and 2014, were evaluated. In a separate subgroup analysis (n=12), paired samples (LM and primary tumor) from the same patient were investigated for IHC profile differences. - Results - LM samples were classified as pancreatobiliary-type (PB-type) in 72 patients (93.5%), intestinal-type (INT-type) in four patients (5.2%), and squamous in one patient (1.3%). There was no significant difference in overall survival (OS) between LM of the PB-type or INT-type (p=0.097). In a multivariate analysis, age <70 years (p=0.047), absence of SMAD4 mutation (p=0.026), absence of CDX2 expression (p=0.003), and well to moderate differentiation were significant prognostic factors for better OS in patients with LM (p=0.031). Analysis of paired tissue samples from LM and the primary tumor revealed a difference in CDX2 (50% increase, p=0.125) and SMAD4 (33% loss of SMAD4, p=0.375). - Conclusions - CDX2 expression and SMAD4 mutation indicate a poor outcome in patients with LM of PDAC. Matched-pair analysis revealed differences in distinct IHC marker expression.
DOI:doi:10.1016/j.pan.2019.09.005
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: https://doi.org/10.1016/j.pan.2019.09.005
 Volltext: http://www.sciencedirect.com/science/article/pii/S1424390319307264
 DOI: https://doi.org/10.1016/j.pan.2019.09.005
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:CDX2
 Epithelial-mesenchymal transition
 Metastases
 Pancreatic cancer
 SMAD4
K10plus-PPN:1684395496
Verknüpfungen:→ Zeitschrift

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