| |  Online-Ressource |
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| Verfasst von: | Held, Thomas [VerfasserIn]  |
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| | Verbeke, Caroline S. [VerfasserIn] |
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| | Strobel, Oliver [VerfasserIn] |
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| | Rutkowski, Wiktor [VerfasserIn] |
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| | Villard, Christina [VerfasserIn] |
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| | Moro, Carlos Fernández [VerfasserIn] |
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| | Del Chiaro, Marco [VerfasserIn] |
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| | Büchler, Markus W. [VerfasserIn] |
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| | Heuchel, Rainer [VerfasserIn] |
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| | Löhr, J.-Matthias [VerfasserIn] |
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| Titel: | Immunohistochemical profiling of liver metastases and matched-pair analysis in patients with metastatic pancreatic ductal adenocarcinoma |
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| Verf.angabe: | Thomas Held, Caroline S. Verbeke, Oliver Strobel, Wiktor Rutkowski, Christina Villard, Carlos Fernández Moro, Marco Del Chiaro, Markus Büchler, Rainer Heuchel, Matthias Löhr |
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| E-Jahr: | 2019 |
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| Jahr: | 14 September 2019 |
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| Umfang: | 8 S. |
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| Fussnoten: | Gesehen am 05.12.2019 |
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| Titel Quelle: | Enthalten in: Pancreatology |
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| Ort Quelle: | Amsterdam : Elsevier, 2001 |
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| Jahr Quelle: | 2019 |
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| Band/Heft Quelle: | 19(2019), 7, Seite 963-970 |
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| ISSN Quelle: | 1424-3911 |
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| Abstract: | Background - The purpose of the current study was to investigate the immunohistochemical (IHC) profile of liver metastases (LM) in patients with pancreatic ductal adenocarcinoma (PDAC). - Methods - Expression of 15 IHC markers in liver biopsies from 77 patients with PDAC, who were diagnosed between 2010 and 2014, were evaluated. In a separate subgroup analysis (n=12), paired samples (LM and primary tumor) from the same patient were investigated for IHC profile differences. - Results - LM samples were classified as pancreatobiliary-type (PB-type) in 72 patients (93.5%), intestinal-type (INT-type) in four patients (5.2%), and squamous in one patient (1.3%). There was no significant difference in overall survival (OS) between LM of the PB-type or INT-type (p=0.097). In a multivariate analysis, age <70 years (p=0.047), absence of SMAD4 mutation (p=0.026), absence of CDX2 expression (p=0.003), and well to moderate differentiation were significant prognostic factors for better OS in patients with LM (p=0.031). Analysis of paired tissue samples from LM and the primary tumor revealed a difference in CDX2 (50% increase, p=0.125) and SMAD4 (33% loss of SMAD4, p=0.375). - Conclusions - CDX2 expression and SMAD4 mutation indicate a poor outcome in patients with LM of PDAC. Matched-pair analysis revealed differences in distinct IHC marker expression. |
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| DOI: | doi:10.1016/j.pan.2019.09.005 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1016/j.pan.2019.09.005 |
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| | Volltext: http://www.sciencedirect.com/science/article/pii/S1424390319307264 |
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| | DOI: https://doi.org/10.1016/j.pan.2019.09.005 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | CDX2 |
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| | Epithelial-mesenchymal transition |
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| | Metastases |
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| | Pancreatic cancer |
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| | SMAD4 |
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| K10plus-PPN: | 1684395496 |
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| Verknüpfungen: | → Zeitschrift |
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Immunohistochemical profiling of liver metastases and matched-pair analysis in patients with metastatic pancreatic ductal adenocarcinoma / Held, Thomas [VerfasserIn]; 14 September 2019 (Online-Ressource)
