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Status: Bibliographieeintrag

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Verfasst von:Wang, Zhe [VerfasserIn]   i
 Zöller, Margot [VerfasserIn]   i
Titel:Exosomes, metastases, and the miracle of cancer stem cell markers
Verf.angabe:Zhe Wang, Margot Zöller
E-Jahr:2019
Jahr:27 April 2019
Umfang:37 S.
Fussnoten:Gesehen am 10.12.2019
Titel Quelle:Enthalten in: Cancer and metastasis reviews
Ort Quelle:Dordrecht [u.a.] : Springer Science + Business Media B.V., 1982
Jahr Quelle:2019
Band/Heft Quelle:38(2019), 1, Seite 259-295
ISSN Quelle:1573-7233
Abstract:Cancer-initiating cells (CIC) are the driving force in tumor progression. There is strong evidence that CIC fulfill this task via exosomes (TEX), which modulate and reprogram stroma, nontransformed cells, and non-CIC. Characterization of CIC, besides others, builds on expression of CIC markers, many of which are known as metastasis-associated molecules. We here discuss that the linkage between CIC/CIC-TEX and metastasis-associated molecules is not fortuitously, but relies on the contribution of these markers to TEX biogenesis including loading and TEX target interactions. In addition, CIC markers contribute to TEX binding- and uptake-promoted activation of signaling cascades, transcription initiation, and translational control. Our point of view will be outlined for pancreas and colon CIC highly expressing CD44v6, Tspan8, EPCAM, claudin7, and LGR5, which distinctly but coordinately contribute to tumor progression. Despite overwhelming progress in unraveling the metastatic cascade and the multiple tasks taken over by CIC-TEX, there remains a considerable gap in linking CIC biomarkers, TEX, and TEX-initiated target modulation with metastasis. We will try to outline possible bridges, which could allow depicting pathways for new and expectedly powerful therapeutic interference with tumor progression.
DOI:doi:10.1007/s10555-019-09793-6
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1007/s10555-019-09793-6
 DOI: https://doi.org/10.1007/s10555-019-09793-6
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Cancer-initiating cell biomarkers
 Exosome biogenesis and targeting
 Exosome message transfer
 Gastrointestinal cancer
 Metastasis
K10plus-PPN:1684893054
Verknüpfungen:→ Zeitschrift

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