| |  Online-Ressource |
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| Verfasst von: | Zindler, Florian [VerfasserIn]  |
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| | Beedgen, Franziska [VerfasserIn] |
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| | Stengel, Daniel [VerfasserIn] |
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| | Baumann, Lisa [VerfasserIn] |
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| | Braunbeck, Thomas [VerfasserIn] |
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| Titel: | Analysis of tail coiling activity of zebrafish (Danio rerio) embryos allows for the differentiation of neurotoxicants with different modes of action |
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| Verf.angabe: | Florian Zindler, Franziska Beedgen, Diana Brandt, Madeleine Steiner, Daniel Stengel, Lisa Baumann, Thomas Braunbeck |
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| E-Jahr: | 2019 |
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| Jahr: | 10 October 2019 |
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| Umfang: | 9 S. |
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| Fussnoten: | Gesehen am 13.12.2019 |
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| Titel Quelle: | Enthalten in: Ecotoxicology and environmental safety |
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| Ort Quelle: | Amsterdam : Elsevier, 1977 |
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| Jahr Quelle: | 2019 |
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| Band/Heft Quelle: | (2019) Artikel-Nummer 109754, 9 Seiten |
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| ISSN Quelle: | 1090-2414 |
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| Abstract: | In (eco)toxicology, there is a critical need for efficient methods to evaluate the neurotoxic potential of environmental chemicals. Recent studies proposed analysis of early coiling activity in zebrafish embryos as a powerful tool for the identification of neurotoxic compounds. In order to demonstrate that the analysis of early tail movements of zebrafish embryos allows for the discrimination of neurotoxicants acting via different mechanisms, the present study investigated the effects of four different neurotoxicants on the embryogenesis (fish embryo toxicity test) and early tail coiling movements of zebrafish embryos. Cadmium predominantly increased the frequency of tail coiling at the late pharyngula stage. Dichlorvos delayed embryonic development and caused convulsive tail movements resulting in prolonged duration of tail coils. Embryos exposed to teratogenic concentrations of fluoxetine and citalopram displayed absence of spontaneous tail movements at 24h post-fertilization. In contrast, a non-teratogenic test concentration of citalopram decreased coiling frequency at multiple time points. Results demonstrated that the analysis of tail coiling movements of zebrafish embryos has the potential to discriminate neurotoxic compounds with different primary modes of action. In addition, chemical-induced effects on coiling activity were shown to potentially overlap with effects on embryogenesis. Further studies are needed to clarify the interplay of unspecific developmental toxicity of neurotoxic chemicals and effects resulting from specific neurotoxic mechanisms. |
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| DOI: | doi:10.1016/j.ecoenv.2019.109754 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1016/j.ecoenv.2019.109754 |
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| | Volltext: http://www.sciencedirect.com/science/article/pii/S0147651319310851 |
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| | DOI: https://doi.org/10.1016/j.ecoenv.2019.109754 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Acetylcholine esterase inhibitor |
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| | Heavy metals |
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| | Locomotor activity |
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| | Pesticides |
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| | Selective serotonin reuptake inhibitor |
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| | Spontaneous coiling movements |
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| K10plus-PPN: | 168539759X |
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| Verknüpfungen: | → Zeitschrift |
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Analysis of tail coiling activity of zebrafish (Danio rerio) embryos allows for the differentiation of neurotoxicants with different modes of action / Zindler, Florian [VerfasserIn]; 10 October 2019 (Online-Ressource)
